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Review
. 2023 Dec;23(8):4401-4411.
doi: 10.1007/s10238-023-01137-7. Epub 2023 Jul 12.

Role of long pentraxin PTX3 in cancer

Duo Li  1 , Zhaozhao Hao  1 , Yandong Nan  2 , Yanwei Chen  1
Affiliations
Review

Role of long pentraxin PTX3 in cancer

Duo Li et al. Clin Exp Med. 2023 Dec.

Abstract

Cancer has become a leading cause of death and disease burden worldwide, closely related to rapid socioeconomic development. However, the fundamental reason is the lack of comprehensive understanding of the mechanism of cancer, accurate identification of preclinical cancer, and effective treatment of the disease. Therefore, it is particularly urgent to study specific mechanisms of cancer and develop effective prediction and treatment methods. Long Pentraxin PTX3 is a soluble pattern recognition molecule produced by various cells in inflammatory sites, which plays a role as a promoter or suppressor of cancer in multiple tumors through participating in innate immune response, neovascularization, energy metabolism, invasion, and metastasis mechanisms. Based on this, this article mainly reviews the role of PTX3 in various cancers.

Keywords: Cancer; PTX3; Tumor promotion; Tumor suppression.

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