Representational disparity of sex, race, and ethnicity in presbyopia clinical trials: a cross-sectional study

doi:10.1038/s41433-023-02621-w

. 2023 Dec;37(18):3871-3873.

doi: 10.1038/s41433-023-02621-w. Epub 2023 Jul 12.

Representational disparity of sex, race, and ethnicity in presbyopia clinical trials: a cross-sectional study

Brendan K Tao¹, Amir R Vosoughi², Bonnie He³, Jennifer Ling⁴, Manvis Xia⁵, Guillermo Rocha², Edsel Ing^{6

7}, Faisal Khosa⁸

Affiliations

¹ Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
² Department of Ophthalmology, University of Manitoba, Winnipeg, MB, Canada.
³ Department of Ophthalmology & Visual Sciences, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
⁴ Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
⁵ Faculty of Science, The University of British Columbia, Vancouver, BC, Canada.
⁶ Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.
⁷ Department of Ophthalmology & Visual Sciences, University of Alberta, Edmonton, AB, Canada.
⁸ Department of Radiology, Vancouver General Hospital, The University of British Columbia, Vancouver, BC, Canada. fkhosa@gmail.com.

PMID: 37438570
PMCID: PMC10697932
DOI: 10.1038/s41433-023-02621-w

Representational disparity of sex, race, and ethnicity in presbyopia clinical trials: a cross-sectional study

Brendan K Tao et al. Eye (Lond). 2023 Dec.

. 2023 Dec;37(18):3871-3873.

doi: 10.1038/s41433-023-02621-w. Epub 2023 Jul 12.

Authors

Brendan K Tao¹, Amir R Vosoughi², Bonnie He³, Jennifer Ling⁴, Manvis Xia⁵, Guillermo Rocha², Edsel Ing^{6

7}, Faisal Khosa⁸

Affiliations

¹ Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
² Department of Ophthalmology, University of Manitoba, Winnipeg, MB, Canada.
³ Department of Ophthalmology & Visual Sciences, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
⁴ Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
⁵ Faculty of Science, The University of British Columbia, Vancouver, BC, Canada.
⁶ Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.
⁷ Department of Ophthalmology & Visual Sciences, University of Alberta, Edmonton, AB, Canada.
⁸ Department of Radiology, Vancouver General Hospital, The University of British Columbia, Vancouver, BC, Canada. fkhosa@gmail.com.

PMID: 37438570
PMCID: PMC10697932
DOI: 10.1038/s41433-023-02621-w

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1. Flow diagram of study methods and clinical trial selection.**
Exclusion criteria for brief and full record evaluation are depicted. From 254 records, we included 20 trials for final analysis, whose study characteristics and trial enrolments were ascertained.

See this image and copyright information in PMC

Cited by

Enrolment characteristics in age-related macular degeneration clinical trials: a cross-sectional study.
Tao BK, Xie JS, Leung V, Patel M, Xu J, Lo C, Yan P, Nathoo N, Lam WC, Navajas EV, Muni R, Kohly RP. Tao BK, et al. Eye (Lond). 2025 Apr;39(6):1153-1159. doi: 10.1038/s41433-024-03572-6. Epub 2024 Dec 27. Eye (Lond). 2025. PMID: 39730975

References

1. Berkowitz ST, Groth SL, Gangaputra S, Patel S. Racial/Ethnic Disparities in Ophthalmology Clinical Trials Resulting in US Food and Drug Administration Drug Approvals From 2000 to 2020. JAMA Ophthalmol. 2021;139:629–37. doi: 10.1001/jamaophthalmol.2021.0857. - DOI - PMC - PubMed
1. Hickenbotham A, Roorda A, Steinmaus C, Glasser A. Meta-Analysis of Sex Differences in Presbyopia. Investig Ophthalmol Vis Sci. 2012;53:3215–20. doi: 10.1167/iovs.12-9791. - DOI - PMC - PubMed
1. Birnbaum FA. Gender and Ethnicity of Enrolled Participants in U.S. Food and Drug Administration (FDA) Clinical Trials for Approved Ophthalmological New Molecular Entities. J Natl Med Assoc. 2018;110:473–9. - PubMed
1. Bowe T, Salabati M, Soares RR, Huang C, Singh RP, Khan MA, et al. Racial, Ethnic, and Gender Disparities in Diabetic Macular Edema Clinical Trials. Ophthalmol Retin. 2022;6:531–3. doi: 10.1016/j.oret.2022.01.018. - DOI - PubMed
1. Han X, Lee PY, Liu C, He M. Distribution and progression of add power among people in need of near correction. Clin Exp Ophthalmol. 2018;46:882–7. doi: 10.1111/ceo.13301. - DOI - PMC - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
- PubMed Central

[1] Berkowitz ST, Groth SL, Gangaputra S, Patel S. Racial/Ethnic Disparities in Ophthalmology Clinical Trials Resulting in US Food and Drug Administration Drug Approvals From 2000 to 2020. JAMA Ophthalmol. 2021;139:629–37. doi: 10.1001/jamaophthalmol.2021.0857. - DOI - PMC - PubMed

[2] Berkowitz ST, Groth SL, Gangaputra S, Patel S. Racial/Ethnic Disparities in Ophthalmology Clinical Trials Resulting in US Food and Drug Administration Drug Approvals From 2000 to 2020. JAMA Ophthalmol. 2021;139:629–37. doi: 10.1001/jamaophthalmol.2021.0857. - DOI - PMC - PubMed

[3] Hickenbotham A, Roorda A, Steinmaus C, Glasser A. Meta-Analysis of Sex Differences in Presbyopia. Investig Ophthalmol Vis Sci. 2012;53:3215–20. doi: 10.1167/iovs.12-9791. - DOI - PMC - PubMed

[4] Hickenbotham A, Roorda A, Steinmaus C, Glasser A. Meta-Analysis of Sex Differences in Presbyopia. Investig Ophthalmol Vis Sci. 2012;53:3215–20. doi: 10.1167/iovs.12-9791. - DOI - PMC - PubMed

[5] Birnbaum FA. Gender and Ethnicity of Enrolled Participants in U.S. Food and Drug Administration (FDA) Clinical Trials for Approved Ophthalmological New Molecular Entities. J Natl Med Assoc. 2018;110:473–9. - PubMed

[6] Birnbaum FA. Gender and Ethnicity of Enrolled Participants in U.S. Food and Drug Administration (FDA) Clinical Trials for Approved Ophthalmological New Molecular Entities. J Natl Med Assoc. 2018;110:473–9. - PubMed

[7] Bowe T, Salabati M, Soares RR, Huang C, Singh RP, Khan MA, et al. Racial, Ethnic, and Gender Disparities in Diabetic Macular Edema Clinical Trials. Ophthalmol Retin. 2022;6:531–3. doi: 10.1016/j.oret.2022.01.018. - DOI - PubMed

[8] Bowe T, Salabati M, Soares RR, Huang C, Singh RP, Khan MA, et al. Racial, Ethnic, and Gender Disparities in Diabetic Macular Edema Clinical Trials. Ophthalmol Retin. 2022;6:531–3. doi: 10.1016/j.oret.2022.01.018. - DOI - PubMed

[9] Han X, Lee PY, Liu C, He M. Distribution and progression of add power among people in need of near correction. Clin Exp Ophthalmol. 2018;46:882–7. doi: 10.1111/ceo.13301. - DOI - PMC - PubMed

[10] Han X, Lee PY, Liu C, He M. Distribution and progression of add power among people in need of near correction. Clin Exp Ophthalmol. 2018;46:882–7. doi: 10.1111/ceo.13301. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Representational disparity of sex, race, and ethnicity in presbyopia clinical trials: a cross-sectional study

Affiliations

Representational disparity of sex, race, and ethnicity in presbyopia clinical trials: a cross-sectional study

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

Cited by

References

MeSH terms

LinkOut - more resources

Full Text Sources