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. 2023 Aug;20(8):e202300427.
doi: 10.1002/cbdv.202300427. Epub 2023 Jul 25.

P2X7-Receptor Pathway Involvement in the Anti-Inflammatory Activity of Medicinal Plants

Sergio Ortiz  1   2 , Katarina Šavikin  3 , France Massicot  4 , Elodie Olivier  4 , Melody Dutot  4 , Patrice Rat  4 , Brigitte Deguin  1 , Dejan Gođevac  5 , Nebojša Menković  3 , Jelena Živković  3 , Gordana Zdunić  3 , Sabrina Boutefnouchet  1
Affiliations

P2X7-Receptor Pathway Involvement in the Anti-Inflammatory Activity of Medicinal Plants

Sergio Ortiz et al. Chem Biodivers. 2023 Aug.

Abstract

Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.

Keywords: P2X7 receptor; Scrophularia; cinnamoyl-iridoids; dereplication; folk medicine.

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References

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