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Editorial
. 2023 Aug 1;51(8):1100-1102.
doi: 10.1097/CCM.0000000000005939. Epub 2023 Jul 13.

Vitamin C and Sepsis: Is Bayesian Reanalysis Useful to Translate the Results of Frequentist Randomized Trials?

Andre C Kalil  1 , Steven Q Simpson  2
Affiliations
Editorial

Vitamin C and Sepsis: Is Bayesian Reanalysis Useful to Translate the Results of Frequentist Randomized Trials?

Andre C Kalil et al. Crit Care Med. .
No abstract available

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Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

Comment on

References

    1. Angriman F, Muttalib F, Lamontagne F, et al.; LOVIT Investigators: IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial. Crit Care Med. 2023; 51:e152–e156
    1. Lamontagne F, Masse MH, Menard J, et al.; LOVIT Investigators and the Canadian Critical Care Trials Group: Intravenous vitamin C in adults with sepsis in the intensive care unit. N Engl J Med. 2022; 386:2387–2398
    1. Kalil AC: Lack of benefit of high-dose vitamin C, thiamine, and hydrocortisone combination for patients with sepsis. JAMA. 2020; 323:419–420
    1. Kalil AC, Sun J: Bayesian methodology for the design and interpretation of clinical trials in critical care medicine: A primer for clinicians. Crit Care Med. 2014; 42:2267–2277
    1. Yarnell CJ, Abrams D, Baldwin MR, et al.: Clinical trials in critical care: Can a Bayesian approach enhance clinical and scientific decision making? Lancet Respir Med. 2021; 9:207–216