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Editorial
. 2023 Aug 1;51(8):1102-1104.
doi: 10.1097/CCM.0000000000005904. Epub 2023 Jul 13.

Are the Outcomes of a Pig Endotoxemia Model Applicable to Human Sepsis?

Nicole B Lyons  1 , Kenneth G Proctor
Affiliations
Editorial

Are the Outcomes of a Pig Endotoxemia Model Applicable to Human Sepsis?

Nicole B Lyons et al. Crit Care Med. .
No abstract available

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Conflict of interest statement

Dr. Proctor disclosed that Osypka Medical has loaned them three icon cardio meters at no charge. Dr. Lyons has disclosed that she does not have any potential conflicts of interest.

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References

    1. Byrne L, Obonyo NG, Diab SD, et al.: Unintended consequences: Fluid resuscitation worsens shock in an ovine model of endotoxemia. Am J Respir Crit Care Med. 2018; 198:1043–1054
    1. Ranjit S, Natraj R, Kandath SK, et al.: Early norepinephrine decreases fluid and ventilatory requirements in pediatric vasodilatory septic shock. Indian J Crit Care Med. 2016; 20:561–569
    1. Li Y, Li H, Zhang D: Timing of norepinephrine initiation in patients with septic shock: A systematic review and meta-analysis. Crit Care. 2020; 24:488
    1. Ospina-Tascón GA, Aldana JL, García Marín AF, et al.: Immediate Norepinephrine in Endotoxic Shock: Effects on Regional and Microcirculatory Flow. Crit Care Med. 2023; 51:e157–e168
    1. Alexander HR, Doherty GM, Buresh CM, et al.: A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice. J Exp Med. 1991; 173:1029–1032

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