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Randomized Controlled Trial
. 2023 Nov;37(8):859-871.
doi: 10.1037/neu0000918. Epub 2023 Jul 13.

Central executive training for ADHD: Impact on organizational skills at home and school. A randomized controlled trial

Affiliations
Randomized Controlled Trial

Central executive training for ADHD: Impact on organizational skills at home and school. A randomized controlled trial

Elizabeth S M Chan et al. Neuropsychology. 2023 Nov.

Abstract

Objective: The current randomized controlled trial (RCT) was the first to examine the benefits of central executive training (CET, which trains the working components of working memory [WM]) for reducing organizational skills difficulties relative to a carefully matched neurocognitive training intervention (inhibitory control training [ICT]).

Method: A carefully phenotyped sample of 73 children with attention-deficit/hyperactivity-impulsivity disorder (ADHD; ages 8-13, M = 10.15, SD = 1.43; 20 girls; 73% White/Non-Hispanic) participated in a preregistered RCT of CET versus ICT (both 10-week treatments). Parent-rated task planning, organized actions, and memory/materials management data were collected at pretreatment, posttreatment, and 2-4 month follow-up; teacher ratings were obtained at pretreatment and 1-2 month follow-up.

Results: CET was superior to ICT for improving organizational skills based on teacher report (Treatment × Time interaction: d = 0.61, p = .01, BF₁₀ = 31.61). The CET group also improved significantly based on parent report, but this improvement was equivalent in both groups (main effect of time: d = 0.48, p < .001, BF₁₀ = 3.13 × 10⁷; Treatment × Time interaction: d = 0.29, p = .25, BF₀₁ = 3.73). Post hocs/preregistered planned contrasts indicated that CET produced significant and clinically meaningful (number needed to treat = 3-8) pre/post gains on all three parent (d = 0.50 -0.62) and all three teacher (d = 0.46 -0.95) subscales, with gains that were maintained at 1-2 month (teacher report) and 2-4 month follow-up (parent report) for five of six outcomes.

Conclusions: Results provide strong initial evidence that CET produces robust and lasting downstream improvements in school-based organizational skills for children with ADHD based on teacher report. These findings are generally consistent with model-driven predictions that ADHD-related organizational problems are secondary outcomes caused, at least in part, by underdeveloped working memory abilities. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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Conflict of interest statement

Conflict of Interest:

The principal investigator Michael Kofler/Florida State University (FSU) was awarded U.S. Patent 11,210,967 for the neurocognitive interventions described in the present study. Central Executive Training was recently licensed to Sky Therapeutics, where Michael Kofler is in negotiations to serve as consultant. There are no other financial or other conflicts to report.

Figures

Figure 1.
Figure 1.
CONSORT diagram. The 115 children assessed for eligibility include all children recruited for evaluation in our research clinic during the study timespan, regardless of recruitment reason (because families would have been offered the intervention trial if their child was diagnosed with ADHD and otherwise eligible). The number of confirmed ADHD cases who were considered for eligibility is 85, of which 73 (85.9%) were randomized and treated/analyzed.

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