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Review
. 2023:1415:223-227.
doi: 10.1007/978-3-031-27681-1_32.

Axonal Transport Defects in Retinal Ganglion Cell Diseases

Iskalen Cansu Topcu Okan  1 , Fatma Ozdemir  1 , Cavit Agca  2   3
Affiliations
Review

Axonal Transport Defects in Retinal Ganglion Cell Diseases

Iskalen Cansu Topcu Okan et al. Adv Exp Med Biol. 2023.

Abstract

For the survival and maintenance of retinal ganglion cells (RGCs), axonal transportation is fundamental. Axonal transportation defects can cause severe neuropathies leading to neuronal loss. Axonal transport defects usually precede axonal degeneration and RGC loss in disease models. To date, the main causes of axonal transport defects have not been fully understood. Therefore, elucidation of the mechanisms that lead to transport defects will help us to develop novel therapeutic targets and early diagnostic tools. In this review, we provide an overview of optic neuropathies and axonal degeneration with a focus on axonal transport.

Keywords: Axonal degeneration; Axonal transport; Glaucoma; Mitochondria; OPA1.

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References

    1. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. The cytoskeleton. In: Bochicchio A, editor. Molecular biology of the cell. New York: Taylor and Francis Group; 2014. p. 939–47.
    1. Hirokawa N, Niwa S, Tanaka Y. Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron. 2010;68(4):610–38. - DOI - PubMed
    1. Reck-Peterson SL, Redwine WB, Vale RD, Carter AP. The cytoplasmic dynein transport machinery and its many cargoes. Nat Rev Mol Cell Biol. 2018;19(6):382–98. - DOI - PubMed - PMC
    1. Yu D-Y, Cringle SJ, Balaratnasingam C, Morgan WH, Paula KY, Su E-N. Retinal ganglion cells: energetics, compartmentation, axonal transport, cytoskeletons and vulnerability. Prog Retin Eye Res. 2013;36:217–46. - DOI - PubMed
    1. Morgan JE. Circulation and axonal transport in the optic nerve. Eye. 2004;18(11):1089–95. - DOI - PubMed

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