doi: 10.1007/978-3-031-27681-1_39.
Photoreceptor Ion Channels in Signaling and Disease
Affiliations
- PMID: 37440044
- DOI: 10.1007/978-3-031-27681-1_39
Item in Clipboard
Photoreceptor Ion Channels in Signaling and Disease
Adv Exp Med Biol.
2023.
Abstract
Photoreceptors (PRs) in the neural retina convert photon capture into an electrical signal that is communicated across a chemical synapse to second-order neurons in the retina and on through the rest of the visual pathway. This information is decoded in the visual cortex to create images. The activity of PRs depends on the concerted action of several voltage-gated ion channels that will be discussed in this chapter.
Keywords: CNG; Cav1.4; HCN1; Ion channels; Kv2.1; Kv8.2; Photoreceptors; Retinal degeneration.
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Similar articles
-
Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.Int J Mol Sci. 2018 Mar 7;19(3):749. doi: 10.3390/ijms19030749. Int J Mol Sci. 2018. PMID: 29518895 Free PMC article. Review.
-
Retinal bipolar neurons express the cyclic nucleotide-gated channel of cone photoreceptors.J Neurophysiol. 2003 Feb;89(2):754-61. doi: 10.1152/jn.00771.2002. J Neurophysiol. 2003. PMID: 12574453
-
Heteromeric KV2/KV8.2 Channels Mediate Delayed Rectifier Potassium Currents in Primate Photoreceptors.J Neurosci. 2018 Apr 4;38(14):3414-3427. doi: 10.1523/JNEUROSCI.2440-17.2018. Epub 2018 Feb 26. J Neurosci. 2018. PMID: 29483285 Free PMC article.
-
The structure of cyclic nucleotide-gated channels in rod and cone photoreceptors.Trends Neurosci. 2022 Oct;45(10):763-776. doi: 10.1016/j.tins.2022.07.001. Epub 2022 Aug 5. Trends Neurosci. 2022. PMID: 35934530 Review.
-
Cyclic-nucleotide-gated channels mediate synaptic feedback by nitric oxide.Nature. 1997 Dec 18-25;390(6661):694-8. doi: 10.1038/37803. Nature. 1997. PMID: 9414163 Free PMC article.
Cited by
-
Ion Channels in Odor Information Processing of Neural Circuits of the Vertebrate Olfactory Bulb.Int J Mol Sci. 2024 Dec 10;25(24):13259. doi: 10.3390/ijms252413259. Int J Mol Sci. 2024. PMID: 39769024 Free PMC article. Review.
-
Atp1b2Atp1b1 Knock-In Mice Exhibit a Cone-Rod Dystrophy-Like Phenotype.Cells. 2025 Jun 11;14(12):878. doi: 10.3390/cells14120878. Cells. 2025. PMID: 40558505 Free PMC article.
References
-
- Pearring JN, Salinas RY, Baker SA, Arshavsky VY. Protein sorting, targeting and trafficking in photoreceptor cells. Prog Retin Eye Res. 2013;36:24–51. - PubMed
-
- Biel M, Michalakis S. Cyclic nucleotide-gated channels. Handb Exp Pharmacol. 2009;191:111–36.
-
- Craven KB, Zagotta WN. CNG and HCN channels: two peas, one pod. Annu Rev Physiol. 2006;68:375–401. - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
