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. 2023:1415:297-301.
doi: 10.1007/978-3-031-27681-1_43.

Retinal Pathoconnectomics: A Window into Neurodegeneration

Rebecca L Pfeiffer  1 , Bryan W Jones  2
Affiliations

Retinal Pathoconnectomics: A Window into Neurodegeneration

Rebecca L Pfeiffer et al. Adv Exp Med Biol. 2023.

Abstract

Over the past decade, the field of retinal connectomics has made huge strides in describing the precise topologies underlying retinal visual processing. The same techniques that allowed these advancements are also applicable to understanding the progression of rewiring in retinal remodeling: retinal pathoconnectomics. Pathoconnectomics is unique in its unbiased approach to understanding the impacts of deafferentation on the remaining network components and identifying aberrant connectivities leading to visual processing defects. Pathoconnectomics also paves the way for identifying underlying rules of rewiring that may be recapitulated throughout the nervous system in other neurodegenerative diseases.

Keywords: Connectomics; Early retinal degeneration; Neural networks; Neurodegeneration; Pathoconnectome; Retinal remodeling; Ultrastructure.

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