Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Aug 7;222(8):e202306126.
doi: 10.1083/jcb.202306126. Epub 2023 Jul 13.

Oiling the wheels of nuclear division: SUMOylation regulates the expansion of the mitotic nuclear membrane

Symeon Siniossoglou  1
Affiliations
Comment

Oiling the wheels of nuclear division: SUMOylation regulates the expansion of the mitotic nuclear membrane

Symeon Siniossoglou. J Cell Biol. .

Abstract

Eukaryotic cell division involves the segregation of chromosomes between two daughter cells and must be coordinated with extensive rearrangement of their nuclear envelopes. In this issue, Saik et al. (2023 J. Cell Biol. https://doi.org/10.1083/jcb.202208137) show that a SUMOylation cascade at the inner nuclear membrane elevates the levels of phosphatidic acid, a key phospholipid precursor, to support the need for nuclear membrane expansion during mitosis.

PubMed Disclaimer

Comment on

References

    1. Makarova, M., and Oliferenko S.. 2016. Curr. Opin. Cell Biol. 10.1016/j.ceb.2016.03.016 - DOI - PMC - PubMed
    1. Santos-Rosa, H., et al. . 2005. EMBO J. 10.1038/sj.emboj.7600672 - DOI
    1. Witkin, K.L., et al. . 2012. Curr. Biol. 10.1016/j.cub.2012.04.022 - DOI - PubMed
    1. Saik, N.O., et al. . 2023. J. Cell Biol. 10.1083/jcb.202208137 - DOI - PMC - PubMed
    1. Ptak, C., et al. . 2021. J. Cell Biol. 10.1083/jcb.202103036 - DOI

Publication types

Substances