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Review
. 2023 Jul-Aug;13(4):649-655.
doi: 10.1016/j.jceh.2022.11.003. Epub 2022 Nov 11.

Guideline Review: European Association for the Study of Liver (EASL) Clinical Practice Guidelines on Haemochromatosis

James Liu Yin  1 , Christopher Cussen  2 , Christopher Harrington  3   4 , Pierre Foskett  4 , Kishor Raja  5 , Aftab Ala  1   2   6
Affiliations
Review

Guideline Review: European Association for the Study of Liver (EASL) Clinical Practice Guidelines on Haemochromatosis

James Liu Yin et al. J Clin Exp Hepatol. 2023 Jul-Aug.

Abstract

The European Association for the Study of the Liver (EASL) has recently (June 2022) produced new clinical practice guidelines for the investigation and management of haemochromatosis, to replace the previous document published in 2010. Here, we provide an overview of the principal changes recommended for the investigation and management of haemochromatosis arising from these guidelines and highlight particular areas where evidence is lacking and where future focus on specific research would improve patient treatment and outcomes. The guideline provides several important new recommendations that will have a meaningful impact on patient management. Specifically, the use of hepatic elastography as a non-invasive assessment of fibrosis, erythrocytapheresis as an alternative treatment modality to classical phlebotomy, surveillance for hepatocellular carcinoma, dietary recommendations in patients with haemochromatosis and guidance on controversial topics including the management of P.C282Y/p.H63D compound heterozygotes, which have been a source of controversy within the field. It is anticipated that the new guidance will affect the management of haemochromatosis patients commonly seen in gastroenterology, liver and related clinics (e.g. haematology and rheumatology) and with this publication we intend to highlight these changes so as to empower clinicians with the confidence to bring these improvements to their translational practice in the treatment of these patients.

Keywords: EASL; guideline review; haemochromatosis; liver disease.

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Figures

Figure 1
Figure 1
Diagnostic pathway of haemochromatosis.
Figure 2
Figure 2
Management pathway of haemochromatosis.
See this image and copyright information in PMC

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References

    1. Porto G., Brissot P., Swinkels D.W., et al. EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH) Eur J Hum Genet. 2016;24:479–495. - PMC - PubMed
    1. European Association for the Study of the Liver EASL clinical practice guidelines for HFE hemochromatosis. J Hepatol [Internet] 2010;53:3–22. doi: 10.1016/j.jhep.2010.03.001. Available from: - DOI - PubMed
    1. Atkins J.L., Pilling L.C., Torti S.V., Torti F.M., Kuchel G.A., Melzer D. Hereditary hemochromatosis variant associations with incident nonliver malignancies: 11-year follow-up in UK Biobank. Cancer Epidemiol biomarkers Prev. 2022 Sep;31:1780–1787. a Publ Am Assoc Cancer Res cosponsored by Am Soc Prev Oncol. - PMC - PubMed
    1. Čuljak M. Hemochromatosis treatment by venipuncture through history. Southeast Eur Med J. 2018;2:44–48.
    1. York Health Economics Consortium & Haemochromatosis UK . 2022. Report : Evaluating the Cost of Illness of Genetic Haemochromatosis in the UK.https://www.haemochromatosis.org.uk/shop/report-evaluating-the-cost-of-i... [Internet] Available from: