Erratum: Blood B cell depletion reflects immunosuppression induced by live-attenuated infectious bursal disease vaccines

Abstract

[This corrects the article DOI: 10.3389/fvets.2022.871549.].

Keywords: B cells; IBDV; immunosuppression; live-attenuated vaccine; replication; vaccine safety.

Figure 3

Implementation of a modified European Pharmacopoeia-derived protocol for IBDV immunosuppression testing. (A) Layout of animal experiment 3. Extra analyses compared to animal experiments 1 and 2 appear in red text. (B) Percentage of clinically protected chicks observed after velogenic Newcastle Disease Virus challenge. Different letters indicate statistically significant differences (p < 0.05) between groups using Fisher's exact test with FDR adjustment method for multiple pairwise comparisons. (C) Serological response to NDV vaccination during experiment 3. Horizontal bars indicate the median of each group. Different letters indicate statistically significant differences (p < 0.05) between groups using Kruskal-Wallis test. (D) Blood B cell concentrations prior to NDV vaccination (“15 days,” left panel), and prior to NDV challenge (“29 days,” right panel). Different letters indicate statistically significant differences (p < 0.05) between groups using Kruskal-Wallis test.