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Review
. 2023 Jun 27:10:1167876.
doi: 10.3389/fmed.2023.1167876. eCollection 2023.

The impact of the use of immunosuppressive treatment after an embryo transfer in increasing the rate of live birth

Mihaela Andreescu  1   2
Affiliations
Review

The impact of the use of immunosuppressive treatment after an embryo transfer in increasing the rate of live birth

Mihaela Andreescu. Front Med (Lausanne). .

Abstract

The tolerance of the immune system for the semi-allogeneic embryo is promoted by several factors and the cells involved in the immune system and factors in the mother during pregnancy. The dysregulation of the immune responses between the mother and fetus is a risk factor that raises the likelihood of rejection of the embryo and reproductive failure. To safeguard embryos and prevent immunological attacks, it is critical to suppress immunological rejection and encourage immunological tolerance. Based on current medical literature, it seems that immune cell management through immunosuppressive therapies can address reproductive failures. Immunosuppressive treatment has demonstrated encouraging results in terms of enhancing outcomes related to pregnancy and rates of live birth by regulating the immune responses of mothers and positively impacting the reproductive processes of humans. Currently, there is scarcity of high-quality data regarding the safety and efficacy of immunosuppressive therapies for children and mothers. Therefore, it is important to exercise caution while selecting use of any immunosuppressive therapy in pregnancy. This mini review provides a comprehensive overview of the existing literature regarding the impact of Calcineurin Inhibitors and anti-TNF treatment on improving the live birth rate following embryo transfer.

Keywords: Immunosuppressants; immunotherapy; recurrent pregnancy loss; repeated implantation failure; reproductive immunology.

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Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. (2015) 13:37. doi: 10.1186/s12958-015-0032-1, PMID: - DOI - PMC - PubMed
    1. Lédée N, Petitbarat M, Chevrier L, Vitoux D, Vezmar K, Rahmati M, et al. The uterine immune profile may help women with repeated unexplained embryo implantation failure after in vitro fertilization. Am J Reprod Immunol. (2016) 75:388–401. doi: 10.1111/aji.12483, PMID: - DOI - PMC - PubMed
    1. Benkhalifa M, Demirol A, Sari T, Balashova E, Tsouroupaki M, Giakoumakis Y, et al. Autologous embryo-cumulus cells co-culture and blastocyst transfer in repeated implantation failures: a collaborative prospective randomized study. Zygote. (2012) 20:173–80. doi: 10.1017/s0967199411000062, PMID: - DOI - PubMed
    1. Zegers-Hochschild F, Adamson GD, De Mouzon J, Ishihara O, Mansour R, Nygren K, et al. The international committee for monitoring assisted reproductive technology (ICMART) and the world health organization (WHO) revised glossary on ART terminology, 2009. Hum Reprod. (2009) 24:2683–7. doi: 10.1093/humrep/dep343, PMID: - DOI - PubMed
    1. Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, et al. Recurrent implantation failure: definition and management. Reprod Biomed Online. (2014) 28:14–38. doi: 10.1016/j.rbmo.2013.08.011 - DOI - PubMed

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