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. 2023 Aug:113:105497.
doi: 10.1016/j.parkreldis.2023.105497. Epub 2023 Jul 12.

Exercise knowledge, barriers and motivators among LRRK2 G2019S mutation carriers

S Schootemeijer  1 , D Coker  2 , J F Shelton  2 , E Chanoff  2 , H M Rowbotham  2 , S K L Darweesh  1 ; 23and Me Research Team; B R Bloem  3 , P Cannon  2 , N M de Vries  1
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Free article

Exercise knowledge, barriers and motivators among LRRK2 G2019S mutation carriers

S Schootemeijer et al. Parkinsonism Relat Disord. 2023 Aug.
Free article

Abstract

Introduction: People with a Gly2019Ser mutation in the leucine-rich repeat kinase 2 (LRRK2 G2019S) are at increased risk of developing Parkinson's disease (PD). Recent evidence suggests that exercise may delay or prevent the development of clinically overt symptoms of PD in people at risk of PD. We determined whether LRRK2 G2019S mutation carriers with and without manifest PD are aware of the relationship between exercise and PD and how they differ in awareness, barriers and motivators to exercise.

Methods: We deployed a survey among 4422 LRRK2 G2019S mutation carriers. In total, 505 (11.4%) of them completed the survey, of whom 105 had self-reported manifest PD.

Results: Ninety-two percent of the LRRK2 G2019S mutation carriers with manifest PD and 63% of those with non-manifest PD were aware of the relationship between exercise and PD. Lack of motivation was the top barrier for those without manifest PD, while having an injury/disability was the most common barrier for those with manifest PD. Improvement of body functioning was the top motivator for both.

Conclusion: The fact that many at-risk individuals are not aware of the importance of exercise and would exercise more with fewer barriers creates opportunities for trials using exercise as a possible prevention strategy for PD.

Keywords: Attitude to health; Exercise; Leucine-rich repeat serine-threonine protein Kinase-2; Motivation; Parkinson's disease.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. D. Coker, J.F. Shelton, E. Chanoff, H.M. Rowbotham, P. Cannon and members of the 23andMe Research Team are employed by and hold stock or stock options in 23andMe, Inc. Prof. Bloem serves as the co-Editor in Chief for the Journal of Parkinson’s disease, serves on the editorial board of Practical Neurology and Digital Biomarkers, has received fees from serving on the scientific advisory board for UCB, Kyowa Kirin, Zambon and the Critical Path Institute (paid to the Institute), has received fees for speaking at conferences from AbbVie, Biogen, UCB, Zambon, Roche, GE Healthcare, Oruen and Bial (paid to the Institute), and has received research support from the Netherlands Organization for Health Research and Development, the Michael J Fox Foundation, UCB, the Stichting Parkinson Fonds, Hersenstichting Nederland, de Stichting Woelse Waard, Stichting Alkemade-Keuls, de Maag Lever Darm Stichting, Parkinson NL, Davis Phinney Foundation, the Parkinson’s Foundation, Verily Life Sciences, Horizon 2020, the Topsector Life Sciences and Health, Nothing Impossible and the Parkinson Vereniging, outside the submitted work. Prof. Bloem does not hold any stocks or stock options with any companies that are connected to Parkinson’s disease or to any of the topics in this paper.

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