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Review
. 2023 Oct:113:156-165.
doi: 10.1016/j.bbi.2023.07.002. Epub 2023 Jul 11.

Developmental impact of peripheral injury on neuroimmune signaling

Adam J Dourson  1 , Michael P Jankowski  2
Affiliations
Review

Developmental impact of peripheral injury on neuroimmune signaling

Adam J Dourson et al. Brain Behav Immun. 2023 Oct.

Abstract

A peripheral injury drives neuroimmune interactions at the level of the injury and throughout the neuraxis. Understanding these systems will be beneficial in the pursuit to target persistent pain that involves both neural and immune components. In this review, we discuss the impact of injury on the development of neuroimmune signaling, along with data that suggest a possible cellular immune memory. We also discuss the parallel effects of injury in the nervous system and immune related areas including bone marrow, lymph node and central nervous system-related cells. Finally, we relate these findings to patient populations and current research that evaluates human tissue.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1:
Figure 1:
Early life injury results in long-lasting cellular changes in macrophages, but the role that other immune cells (dendritic cells, neutrophils, T cells), sex differences, and ages play in prolonged responsiveness after neonatal insult need to be determined more broadly in future studies.
Figure 2:
Figure 2:
Peripheral injuries result in neuroimmune interactions at the site of damage and within the nerve, DRG and central nervous system. Signaling at other areas important for the immune response are also impacted by injury.
See this image and copyright information in PMC

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