Letter to the editor regarding recent publication titled "Developing an internal threshold of toxicological concern (iTTC)" by Arnot et al. (2022)
- PMID: 37443297
- DOI: 10.1038/s41370-023-00571-9
Letter to the editor regarding recent publication titled "Developing an internal threshold of toxicological concern (iTTC)" by Arnot et al. (2022)
Comment on
-
Developing an internal threshold of toxicological concern (iTTC).J Expo Sci Environ Epidemiol. 2022 Nov;32(6):877-884. doi: 10.1038/s41370-022-00494-x. Epub 2022 Nov 8. J Expo Sci Environ Epidemiol. 2022. PMID: 36347933 Free PMC article.
References
-
- Munro IC, Ford RA, Kennepohl E, Sprenger JG. Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern. Food Chem Toxicol. 1996;34:829–67. https://doi.org/10.1016/S0278-6915(96)00049-X . - DOI - PubMed
-
- Rogiers V, Benfenati E, Bernauer U, Bodin L, Carmichael P, Chaudhry Q, et al. The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings. Toxicology. 2020;436:152421. https://doi.org/10.1016/j.tox.2020.152421 . - DOI - PubMed
-
- Bessems JGM, Paini A, Gajewska M, Worth A. The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data – a case study with caffeine. Toxicology. 2017;392:119–29. https://doi.org/10.1016/j.tox.2017.03.012 . - DOI - PubMed
-
- Ellison CA, Blackburn KL, Carmichael PL, Clewell HJ 3rd, Cronin MTD, Desprez B, et al. Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop. Regul Toxicol Pharmacol. 2019;103:63–72. https://doi.org/10.1016/j.yrtph.2019.01.016 . - DOI - PubMed - PMC
-
- Ellison CA, Api AM, Becker RA, Efremenko AY, Gadhia S, Hack CE, et al. Internal Threshold of Toxicological Concern (iTTC): where we are today and what is possible in the near future. Front Toxicol. 2021;2:621541. https://doi.org/10.3389/ftox.2020.621541 . - DOI - PubMed - PMC
Publication types
LinkOut - more resources
Full Text Sources