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. 2023 Jul 7;13(13):2310.
doi: 10.3390/diagnostics13132310.

Is There a Potential Link between Gastroesophageal Reflux Disease and Recurrent Respiratory Tract Infections in Children?

Vasile Valeriu Lupu  1 , Gabriela Stefanescu  2 , Ana Maria Laura Buga  1 , Lorenza Forna  1 , Elena Tarca  3 , Iuliana Magdalena Starcea  1 , Cristina Maria Mihai  4 , Laura Florescu  5 , Andrei Tudor Cernomaz  6 , Adriana Mocanu  1 , Viorel Tarca  7 , Aye Aung Thet  8 , Ancuta Lupu  1
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Is There a Potential Link between Gastroesophageal Reflux Disease and Recurrent Respiratory Tract Infections in Children?

Vasile Valeriu Lupu et al. Diagnostics (Basel). .

Abstract

Background: The implications of gastroesophageal reflux disease in respiratory tract infections have been investigated over time. The aim of our study was to evaluate the relationship between these two pathologic entities and the outcome after proper antireflux treatment.

Methods: A group of 53 children with recurrent respiratory tract infections admitted in the gastroenterology clinic of a children's hospital in North-East Romania was investigated for gastroesophageal reflux disease through 24 h pH-metry. Those with a Boix-Ochoa score higher than 11.99 received proton pump inhibitor treatment and were reevaluated after 2 months.

Results: A total of 41 children were found with a positive Boix-Ochoa score. After 2 months of antireflux therapy, eight patients still had a positive Boix-Ochoa score.

Conclusions: Recurrent respiratory tract infections with symptoms resistant to treatment should be considered a reason to investigate for gastroesophageal reflux, because the symptoms may be due to micro- or macro-aspiration of the gastric refluxate or to an esophageal-bronchial reflex mediated through the vagal nerve.

Keywords: Boix-Ochoa score; children; gastroesophageal reflux disease; pH-metry; recurrent respiratory tract infections.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Rosen R., Vandenplas Y., Singendonk M., Cabana M., DiLorenzo C., Gottrand F., Gupta S., Langendam M., Staiano A., Thapar N., et al. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J. Pediatr. Gastroenterol. Nutr. 2018;66:516–554. doi: 10.1097/MPG.0000000000001889. - DOI - PMC - PubMed
    1. Pados B.F., Davitt E.S. Pathophysiology of Gastroesophageal Reflux Disease in Infants and Nonpharmacologic Strategies for Symptom Management. Nurs. Women’s Health. 2020;24:101–114. doi: 10.1016/j.nwh.2020.01.005. - DOI - PubMed
    1. Jones A.B. Gastroesophageal reflux in infants and children. When to reassure and when to go further. Can. Fam. Physician. 2001;47:2045–2050, 2053. - PMC - PubMed
    1. Orenstein S.R. Update on gastroesophageal reflux and respiratory disease in children. Can. J. Gastroenterol. 2000;14:131–135. doi: 10.1155/2000/918745. - DOI - PubMed
    1. Karbasi A., Ardestani M.E., Ghanei M., Harandi A.A. The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux. J. Res. Med. Sci. 2013;18:473–476. - PMC - PubMed

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