Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul 6;12(13):1797.
doi: 10.3390/cells12131797.

Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review

Giuseppina Malcangi  1 , Assunta Patano  1 , Giulia Palmieri  1 , Chiara Di Pede  1 , Giulia Latini  1 , Alessio Danilo Inchingolo  1 , Denisa Hazballa  1 , Elisabetta de Ruvo  1 , Grazia Garofoli  1 , Francesco Inchingolo  1 , Gianna Dipalma  1 , Elio Minetti  2 , Angelo Michele Inchingolo  1
Affiliations

Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review

Giuseppina Malcangi et al. Cells. .

Abstract

Background: The current review aims to provide an overview of the most recent research on the potentials of concentrated growth factors used in the maxillary sinus lift technique.

Materials and methods: "PRP", "PRF", "L-PRF", "CGF", "oral surgery", "sticky bone", "sinus lift" were the search terms utilized in the databases Scopus, Web of Science, and Pubmed, with the Boolean operator "AND" and "OR".

Results: Of these 1534 studies, 22 publications were included for this review.

Discussion: The autologous growth factors released from platelet concentrates can help to promote bone remodeling and cell proliferation, and the application of platelet concentrates appears to reduce the amount of autologous bone required during regenerative surgery. Many authors agree that growth factors considerably enhance early vascularization in bone grafts and have a significantly positive pro-angiogenic influence in vivo when combined with alloplastic and xenogeneic materials, reducing inflammation and postoperative pain and stimulating the regeneration of injured tissues and accelerating their healing.

Conclusions: Even if further studies are still needed, the use of autologous platelet concentrates can improve clinical results where a large elevation of the sinus is needed by improving bone height, thickness and vascularization of surgical sites, and post-operative healing.

Keywords: CGF; PRF; PRP; Sinus Lift (S.L.); growth factor; oral surgery.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Sticky bone: A compact and plastic compound, evolution of the regenerative technique with CGF.
Figure 2
Figure 2
PRISMA flowchart.
Figure 3
Figure 3
Timing of the sinus lift using lateral window technique.
Figure 4
Figure 4
Section of a CBCT before (A) and after (B) the sinus lift.
Figure 5
Figure 5
(A) Using piezo surgery to open the window of Tatum and protect the arteries and the Schneiderian membrane during the sinus lift graft (B) Views of the antral alveolar artery indicated by arrow.
Figure 6
Figure 6
Surgical approach techniques for sinus lift and timing for implants.
Figure 7
Figure 7
Summer’s technique using CGF graft for sinus lift.
See this image and copyright information in PMC

References

    1. Inchingolo F., Tatullo M., Marrelli M., Inchingolo A.M., Inchingolo A.D., Dipalma G., Flace P., Girolamo F., Tarullo A., Laino L., et al. Regenerative Surgery Performed with Platelet-Rich Plasma Used in Sinus Lift Elevation before Dental Implant Surgery: An Useful Aid in Healing and Regeneration of Bone Tissue. Eur. Rev. Med. Pharmacol. Sci. 2012;16:1222–1226. - PubMed
    1. Marchetti E., Tecco S., Caterini E., Casalena F., Quinzi V., Mattei A., Marzo G. Alcohol-Free Essential Oils Containing Mouthrinse Efficacy on Three-Day Supragingival Plaque Regrowth: A Randomized Crossover Clinical Trial. Trials. 2017;18:154. doi: 10.1186/s13063-017-1901-z. - DOI - PMC - PubMed
    1. Rapone B., Inchingolo A.D., Trasarti S., Ferrara E., Qorri E., Mancini A., Montemurro N., Scarano A., Inchingolo A.M., Dipalma G., et al. Long-Term Outcomes of Implants Placed in Maxillary Sinus Floor Augmentation with Porous Fluorohydroxyapatite (Algipore® FRIOS®) in Comparison with Anorganic Bovine Bone (Bio-Oss®) and Platelet Rich Plasma (PRP): A Retrospective Study. J. Clin. Med. 2022;11:2491. doi: 10.3390/jcm11092491. - DOI - PMC - PubMed
    1. Dohan Ehrenfest D.M., Bielecki T., Mishra A., Borzini P., Inchingolo F., Sammartino G., Rasmusson L., Everts P.A. In Search of a Consensus Terminology in the Field of Platelet Concentrates for Surgical Use: Platelet-Rich Plasma (PRP), Platelet-Rich Fibrin (PRF), Fibrin Gel Polymerization and Leukocytes. Curr. Pharm. Biotechnol. 2012;13:1131–1137. doi: 10.2174/138920112800624328. - DOI - PubMed
    1. Libonati A., Marzo G., Klinger F.G., Farini D., Gallusi G., Tecco S., Mummolo S., De Felici M., Campanella V. Embryotoxicity Assays for Leached Components from Dental Restorative Materials. Reprod. Biol. Endocrinol. 2011;9:136. doi: 10.1186/1477-7827-9-136. - DOI - PMC - PubMed

Publication types

Substances