Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul 6;15(13):3517.
doi: 10.3390/cancers15133517.

Assessment of the Role of Leptin and Adiponectinas Biomarkers in Pancreatic Neuroendocrine Neoplasms

Agnes Bocian-Jastrzębska  1 , Anna Malczewska-Herman  1 , Violetta Rosiek  1 , Beata Kos-Kudła  1
Affiliations

Assessment of the Role of Leptin and Adiponectinas Biomarkers in Pancreatic Neuroendocrine Neoplasms

Agnes Bocian-Jastrzębska et al. Cancers (Basel). .

Abstract

Data on the possible connection between circulating adipokines and PanNENs are limited. This novel study aimed to assess the serum levels of leptin and adiponectin and their ratio in patients with PanNENs and to evaluate the possible relationship between them and PanNEN's grade or stage, including the presence of metastases. The study group consisted of PanNENs (n = 83), and healthy controls (n = 39). Leptin and adiponectin measurement by an ELISA assay was undertaken in the entire cohort. The serum concentration of adiponectin was significantly higher in the control group compared to the study group (p < 0.001). The concentration of leptin and adiponectin was significantly higher in females than in males (p < 0.01). Anincreased leptin-adiponectin ratio was observed in well-differentiated PanNENs (G1) vs. moderatelydifferentiated PanNENs (G2) (p < 0.05). An increased leptin-adiponectin ratio was found in PanNENs with Ki-67 < 3% vs. Ki-67 ≥ 3% (p < 0.05). PanNENs with distal disease presented lower leptin levels (p < 0.001) and a decreased leptin-adiponectin ratio (p < 0.01) compared with the localized disease group. Leptin, adiponectin, and the leptin-adiponectin ratio may serve as potential diagnostic, prognostic, and predictive biomarkers for PanNENs. Leptin levels and the leptin-adiponectin ratio may play an important role as predictors of malignancy and metastasis in PanNENs.

Keywords: adiponectin; leptin; leptin–adiponectin ratio; pancreatic neuroendocrine neoplasm.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mann–Whitney U test. Adiponectin levels in the study and control groups: adiponectin levels were significantly higher in controls vs. the study group (p < 0.001).
Figure 2
Figure 2
Mann–Whitney U test. Leptin–adiponectin ratio in grade 1 vs. 2 PanNENs: increased leptin–adiponectin ratio was observed in grade 1 PanNENs vs. grade 2 PanNENs (p < 0.05).
Figure 3
Figure 3
Mann–Whitney U test.Leptin–adiponectin ratio analyzed by Ki-67 groups: increased leptin–adiponectin ratio was observed in PanNENs with Ki-67 < 3% vs. Ki-67 ≥ 3%(p < 0.05).
Figure 4
Figure 4
Mann–Whitney U test. (a) Leptin levels—analysis by disease extent: PanNENs with distal disease presented lower leptin levels vs. localized disease (p < 0.001); (b) Leptin–adiponectin ratio analyzed by disease extent: PanNENs with distal disease presented decreased leptin–adiponectin ratio vs. localized disease (p < 0.01).
See this image and copyright information in PMC

References

    1. Howe R., Merchant J., Conrad N., Keutgen C., Hallet X., Drebin J., Minter R.M., Lairmore T.C., Tseng J.F., Zeh H.J., et al. The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors. Pancreas. 2020;49:1–33. doi: 10.1097/MPA.0000000000001454. - DOI - PMC - PubMed
    1. Kuo J.H., Lee J.A., Chabot J.A. Nonfunctional pancreatic neuroendocrine tumors. Surg. Clin. N. Am. 2014;94:689–708. doi: 10.1016/j.suc.2014.02.010. - DOI - PubMed
    1. Miller H.C., Drymousis P., Flora R., Goldin R., Spalding D., Frilling A. Role of Ki-67 proliferation index in the assessment of patients with neuroendocrine neoplasias regarding the stage of disease. World J. Surg. 2014;38:1353–1361. doi: 10.1007/s00268-014-2451-0. - DOI - PubMed
    1. Bałdys-Waligórska A., Nowak A. Neuroendocrine neoplasms of the digestive system—Current classification and terminology. Nowotwory. 2021;71:26–37. doi: 10.5603/NJO.2021.0005. - DOI
    1. Nagtegaal I.D., Odze R.D., Klimstra D., Paradis V., Rugge M., Schirmacher P., Washington K.M., Carneiro F., Cree I.A. WHO Classification of Tumours Editorial Board. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76:182–188. doi: 10.1111/his.13975. - DOI - PMC - PubMed

LinkOut - more resources