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. 2023 Jul 7;11(13):1975.
doi: 10.3390/healthcare11131975.

The Prospective Effects of Coping Strategies on Mental Health and Resilience at Five Months after HSCT

Maya Corman  1 , Michael Dambrun  1 , Marie-Thérèse Rubio  2 , Aurélie Cabrespine  3 , Isabelle Brindel  4 , Jacques-Olivier Bay  3 , Régis Peffault de La Tour  4
Affiliations

The Prospective Effects of Coping Strategies on Mental Health and Resilience at Five Months after HSCT

Maya Corman et al. Healthcare (Basel). .

Abstract

Objectives: Hematopoietic stem cell transplantation (HSCT) is a stressful event that engenders psychological distress. This study examines the prospective effects of coping strategies during hospitalization on resilience and on various mental-health dimensions at five months after transplantation.

Methods: One hundred and seventy patients (Mage = 52.24, SD = 13.25) completed a questionnaire assessing adjustment strategies during hospitalization, and 91 filled out a questionnaire five months after HSCT (Mage = 51.61, SD = 12.93).

Results: Multiple regression analyses showed that a fighting spirit strategy positively predicted resilience (p < 0.05), whereas anxious preoccupations predicted anxiety (p < 0.05), poorer mental QoL (p < 0.01), and were associated with an increased risk of developing PTSD (OR = 3.27, p < 0.01; 95% CI: 1.36, 7.84) at five months after transplantation. Hopelessness, avoidance, and denial coping strategies were not predictive of any of the mental health outcomes. Finally, the number of transplantations was negatively related to a fighting spirit (p < 0.01) and positively related to hopelessness-helplessness (p < 0.001): Conclusions: These results highlight the importance of developing psychological interventions focused on coping to alleviate the negative psychological consequences of HSCT.

Keywords: adjustment coping strategies; hematopoietic stem cell transplant (HSCT); mental health; post-traumatic stress disorder; quality of life; resilience.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of protocol.
See this image and copyright information in PMC

References

    1. El-Jawahri A.R., Bs H.B.V., Traeger L.N., Ba J.N.F., Keenan T., Gallagher E.R., Greer J.A., Pirl W.F., Jackson V.A., Spitzer T.R., et al. Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation. Cancer. 2016;122:806–812. doi: 10.1002/cncr.29818. - DOI - PMC - PubMed
    1. Kisch A., Lenhoff S., Zdravkovic S., Bolmsjö I. Factors associated with changes in quality of life in patients undergoing allogeneic haematopoietic stem cell transplantation. Eur. J. Cancer Care. 2012;21:735–746. doi: 10.1111/j.1365-2354.2012.01354.x. - DOI - PubMed
    1. Sun C.-L., Kersey J.H., Francisco L., Armenian S.H., Baker K.S., Weisdorf D.J., Forman S.J., Bhatia S. Burden of morbidity in 10+ year survivors of hematopoietic cell transplantation: Report from the bone marrow transplantation survivor study. Biol. Blood Marrow Transpl. 2013;19:1073–1080. doi: 10.1016/j.bbmt.2013.04.002. - DOI - PMC - PubMed
    1. Pillay B., Lee S.J., Katona L., De Bono S., Burney S., Avery S. A prospective study of the relationship between sense of coherence, depression, anxiety, and quality of life of haematopoietic stem cell transplant patients over time. Psycho-Oncology. 2014;24:220–227. doi: 10.1002/pon.3633. - DOI - PubMed
    1. Artherholt S.B., Hong F., Berry D.L., Fann J.R. Risk factors for depression in patients undergoing hematopoietic cell transplantation. Biol. Blood Marrow Transpl. 2014;20:946–950. doi: 10.1016/j.bbmt.2014.03.010. - DOI - PMC - PubMed

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