Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 6;12(13):4518.
doi: 10.3390/jcm12134518.

Personality Traits and Fatigue in Multiple Sclerosis: A Narrative Review

Alessia Ciancio  1 , Maria Claudia Moretti  2 , Antimo Natale  1 , Alessandro Rodolico  1 , Maria Salvina Signorelli  1 , Antonino Petralia  1 , Mario Altamura  2 , Antonello Bellomo  2 , Aurora Zanghì  3 , Emanuele D'Amico  3 , Carlo Avolio  3 , Carmen Concerto  1
Affiliations
Review

Personality Traits and Fatigue in Multiple Sclerosis: A Narrative Review

Alessia Ciancio et al. J Clin Med. .

Abstract

(1) Background: Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease. Fatigue is a prevalent and debilitating symptom that significantly impacts the quality of life of these patients. A relationship between personality traits and fatigue in MS has been hypothesized but not clearly defined. (2) Methods: A literature search was carried out from databases up to April 2023 for studies correlating personality traits and fatigue in patients suffering from MS. (3) Results: A total of ten articles was included; most of the studies depict a neuroticism-fatigue correlation; however, they were not consistent in terms of the fatigue, personality, and covariate assessments. (4) Conclusions: The clinical and methodological heterogeneity of the included studies prevented us from drawing any firm conclusion on the link between personality traits and fatigue in MS. Several models of personality and different fatigue assessments have been found. Despite this, a common pathway shows that the neuroticism trait or similar personality patterns has a role in fatigue diagnosis. This may be a useful target to improve the quality of life and enhance the modification of the disease treatment results. Further homogeneous and longitudinal studies are needed.

Keywords: big five factor; fatigue; multiple sclerosis; neurodegenerative disease; personality traits.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow chart.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. McGinley M.P., Goldschmidt C.H., Rae-Grant A.D. Diagnosis and Treatment of Multiple Sclerosis: A Review. JAMA. 2021;325:765–779. doi: 10.1001/jama.2020.26858. - DOI - PubMed
    1. D’Amico E., Patti F., Zanghì A., Chisari C.G., Fermo S.L., Zappia M. Late-onset and young-onset relapsing-remitting multiple sclerosis: Evidence from a retrospective long-term follow-up study. Eur. J. Neurol. 2018;25:1425–1431. doi: 10.1111/ene.13745. - DOI - PubMed
    1. Naseri A., Nasiri E., Sahraian M.A., Daneshvar S., Talebi M. Clinical Features of Late-Onset Multiple Sclerosis: A Systematic Review and Meta-analysis. Mult. Scler. Relat. Disord. 2021;50:102816. doi: 10.1016/j.msard.2021.102816. - DOI - PubMed
    1. Zanghì A., Avolio C., Amato M.P., Filippi M., Trojano M., Patti F., D’amico E., Register F.T.I.M. First-line therapies in late-onset multiple sclerosis: An Italian registry study. Eur. J. Neurol. 2021;28:4117–4123. doi: 10.1111/ene.15006. - DOI - PMC - PubMed
    1. Zanghì A., D’amico E., Fermo S.L., Patti F. Exploring polypharmacy phenomenon in newly diagnosed relapsing–remitting multiple sclerosis: A cohort ambispective single-centre study. Ther. Adv. Chronic Dis. 2021;12:2040622320983121. doi: 10.1177/2040622320983121. - DOI - PMC - PubMed

LinkOut - more resources