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Review
. 2023 Jun 27;24(13):10738.
doi: 10.3390/ijms241310738.

Chitosan-Based Antibacterial Films for Biomedical and Food Applications

Omar M Khubiev  1 , Anton R Egorov  1 , Anatoly A Kirichuk  1 , Victor N Khrustalev  1   2 , Alexander G Tskhovrebov  1 , Andreii S Kritchenkov  1   3
Affiliations
Review

Chitosan-Based Antibacterial Films for Biomedical and Food Applications

Omar M Khubiev et al. Int J Mol Sci. .

Abstract

Antibacterial chitosan films, versatile and eco-friendly materials, have garnered significant attention in both the food industry and medicine due to their unique properties, including biodegradability, biocompatibility, and antimicrobial activity. This review delves into the various types of chitosan films and their distinct applications. The categories of films discussed span from pure chitosan films to those enhanced with additives such as metal nanoparticles, metal oxide nanoparticles, graphene, fullerene and its derivatives, and plant extracts. Each type of film is examined in terms of its synthesis methods and unique properties, establishing a clear understanding of its potential utility. In the food industry, these films have shown promise in extending shelf life and maintaining food quality. In the medical field, they have been utilized for wound dressings, drug delivery systems, and as antibacterial coatings for medical devices. The review further suggests that the incorporation of different additives can significantly enhance the antibacterial properties of chitosan films. While the potential of antibacterial chitosan films is vast, the review underscores the need for future research focused on optimizing synthesis methods, understanding structure-property relationships, and rigorous evaluation of safety, biocompatibility, and long-term stability in real-world applications.

Keywords: antibacterial properties; chitosan films; food industry applications; medical applications; nanocomposite materials.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of chitosan.
Figure 2
Figure 2
Processing of chitosan and methods of preparation of chitosan-based films.
Figure 3
Figure 3
Mechanisms of antibacterial action of chitosan.
See this image and copyright information in PMC

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