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Review
. 2023 Jun 28;24(13):10767.
doi: 10.3390/ijms241310767.

Molecular Mechanism in the Development of Pulmonary Fibrosis in Patients with Sarcoidosis

Elisabetta Cocconcelli  1 , Nicol Bernardinello  1 , Gioele Castelli  1 , Simone Petrarulo  1 , Serena Bellani  1 , Marina Saetta  1 , Paolo Spagnolo  1 , Elisabetta Balestro  1
Affiliations
Review

Molecular Mechanism in the Development of Pulmonary Fibrosis in Patients with Sarcoidosis

Elisabetta Cocconcelli et al. Int J Mol Sci. .

Abstract

Sarcoidosis is a multisystemic disease of unknown etiology characterized by the formation of granulomas in various organs, especially lung and mediastinal hilar lymph nodes. The clinical course and manifestations are unpredictable: spontaneous remission can occur in approximately two thirds of patients; up to 20% of patients have chronic course of the lung disease (called advanced pulmonary sarcoidosis, APS) resulting in progressive loss of lung function, sometimes life-threatening that can lead to respiratory failure and death. The immunopathology mechanism leading from granuloma formation to the fibrosis in APS still remains elusive. Recent studies have provided new insights into the genetic factors and immune components involved in the clinical manifestation of the disease. In this review we aim to summarize the clinical-prognostic characteristics and molecular pathways which are believed to be associated with the development of APS.

Keywords: advanced pulmonary fibrosis; molecular pathway; sarcoidosis; signaling.

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Conflict of interest statement

The authors declare no conflict of interest.

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