Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 6;24(13):11176.
doi: 10.3390/ijms241311176.

Advancing Cancer Research: Current Knowledge on Cutaneous Neoplasia

Laura Stătescu  1 , Laura Mihaela Trandafir  2 , Elena Țarcă  3 , Mihaela Moscalu  4 , Maria Magdalena Leon Constantin  5 , Lăcrămioara Ionela Butnariu  2 , Mioara Florentina Trandafirescu  6 , Mihaela Camelia Tîrnovanu  2 , Rodica Heredea  7 , Andrei Valentin Pătrașcu  6 , Doru Botezat  4 , Elena Cojocaru  6
Affiliations
Review

Advancing Cancer Research: Current Knowledge on Cutaneous Neoplasia

Laura Stătescu et al. Int J Mol Sci. .

Abstract

Skin cancers require a multidisciplinary approach. The updated guidelines introduce new insights into the management of these diseases. Melanoma (MM), the third most common skin cancer, a malignant melanocytic tumor, which is classified into four major histological subtypes, continues to have the potential to be a lethal disease. The mortality-incidence ratio is higher in Eastern European countries compared to Western European countries, which shows the need for better prevention and early detection in Eastern European countries. Basal cell carcinoma (BCC) and squamous cell carcinoma (cSCC) remain the top two skin cancers, and their incidence continues to grow. The gold standard in establishing the diagnosis and establishing the histopathological subtype in BCC and SCC is a skin biopsy. Sebaceous carcinoma (SeC) is an uncommon and potentially aggressive cutaneous malignancy showing sebaceous differentiation. It accounts for 0.7% of skin cancers and 3-6.7% of cancer-related deaths. Due to the rapid extension to the regional lymph nodes, SeC requires early treatment. The main treatment for sebaceous carcinoma is surgical treatment, including Mohs micrographic surgery, which has the advantage of complete margin evaluation and low recurrence rates. Primary cutaneous lymphomas (PCLs) are a heterogeneous group of lymphoproliferative diseases, with no evidence of extracutaneous determination at the moment of the diagnosis. PCLs have usually a very different evolution, prognosis, and treatment compared to the lymphomas that may secondarily involve the skin. The aim of our review is to summarize the important changes in the approach to treating melanoma, non-melanoma skin, cutaneous T and B cell lymphomas, and other types of skin cancers. For all skin cancers, optimal patient management requires a multidisciplinary approach including dermatology, medical oncology, and radiation oncology.

Keywords: cutaneous lymphoma; malignant melanoma; non-melanocytic skin cancer.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Michielin O., van Akkooi A.C.J., Ascierto P., Dummer R., Keilholz U., on behalf of the ESMO Guidelines Committee Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2019;30:1884–1901. doi: 10.1093/annonc/mdz411. - DOI - PubMed
    1. Rebecca I., Hartman R., Lin J.Y. Cutaneous Melanoma—A Review in Detection, Staging, and Management. Hematol. Oncol. Clin. N. Am. 2019;33:25–38. - PubMed
    1. National Cancer Institute Adolescents and Young Adults with Cancer. [(accessed on 25 May 2023)]; Available online: https://www.cancer.gov/types/aya.
    1. Forsea A., del Marmol V., Stratigos A., Geller A. Melanoma prognosis in Europe: Far from equal. Br. J. Dermatol. 2014;171:179–182. doi: 10.1111/bjd.12923. - DOI - PubMed
    1. Dessinioti C., Stratigos A. Overview of guideline recommendations for the management of high-risk and advanced cutaneous squamous cell carcinoma. J. Eur. Acad. Dermatol. Venereol. 2021;36((Suppl. S1)):11–18. doi: 10.1111/jdv.17531. - DOI - PubMed

MeSH terms