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. 2023 Jul 3;13(13):2000.
doi: 10.3390/nano13132000.

Fabrication and Characterization of Polylactic Acid Electrospun Wound Dressing Modified with Polyethylene Glycol, Rosmarinic Acid and Graphite Oxide

Chengyi Liu  1 , Guicai Du  1 , Qunqun Guo  1 , Ronggui Li  1 , Changming Li  2 , Hongwei He  3
Affiliations

Fabrication and Characterization of Polylactic Acid Electrospun Wound Dressing Modified with Polyethylene Glycol, Rosmarinic Acid and Graphite Oxide

Chengyi Liu et al. Nanomaterials (Basel). .

Abstract

Polylactic acid (PLA) is a biodegradable polymer made from natural sources, and its electrospinning (e-spinning) nanofiber membrane doped with antibacterial ingredients is widely used in the field of medical dressings. In this research, 9 wt% of rosmarinic acid (RosA) and 0.04 wt% of graphite oxide (GO) with synergistic antibacterial activity were introduced into the e-spinning PLA precursor solution, and the obtained PLA nanofiber membrane showed good antibacterial properties and wound healing effects. At the same time, a nonionic amphiphilic polymer, polyethylene glycol (PEG), was also introduced into this system to improve the hydrophilicity of the e-spinning membrane for wound healing application. The morphological characterization showed the RosA/GO and PEG did not affect the e-spinning of PLA. The tests of mechanical performance and wettability demonstrated that PEG and RosA/GO incorporated in PLA have migrated easily to the surface of the fiber. The e-spun PLA/PEG/RosA/GO membrane showed good antibacterial activity and promoted initial wound healing quickly, which would be a promising application in wound dressing.

Keywords: PLA nanofiber; electrospinning; rosmarinic acid; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Illustration of a home-made e-spinning equipment.
Figure 2
Figure 2
SEM images of electrospun composite nanofiber membrane: (a) pure PLA, (b) PLA/RosA/GO, (c) PLA/PEG/RosA/GO, (d) average diameter of fibers (a–c).
Figure 3
Figure 3
(a) FT-IR spectra and (b) XRD patterns of as-spun composite nanofiber membranes.
Figure 4
Figure 4
(a) DSC and (b) TG curves of as-spun composite nanofiber.
Figure 5
Figure 5
Stress-strain curve of the e-spun nanofiber membranes.
Figure 6
Figure 6
Water contact angle (CA) of the e-spun nanofiber membranes.
Figure 7
Figure 7
(a) Pore distribution, (b) porosity and (c) permeability of the e-spun nanofiber membranes.
Figure 8
Figure 8
Evaluation of antibacterial activity of as-spun membranes: (a,d) pure PLA; (b,e) PLA/RosA/GO; (c,f) PLA/PEG/RosA/GO.
Figure 9
Figure 9
Photos of the status of wound healing for different membranes at 1, 3, 5, 7, 9, 11 days.
Figure 10
Figure 10
Healing rate of different treatment groups.
See this image and copyright information in PMC

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