Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun 28;28(13):5052.
doi: 10.3390/molecules28135052.

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

Mu Guo  1   2 , Xiangbin Yu  1   2 , Yi Zhun Zhu  3 , Yue Yu  1   2
Affiliations
Review

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

Mu Guo et al. Molecules. .

Abstract

Imidazothiazole derivatives are becoming increasingly important in therapeutic use due to their outstanding physiological activities. Recently, applying imidazothiazole as the core, researchers have synthesized a series of derivatives with biological effects such as antitumor, anti-infection, anti-inflammatory and antioxidant effects. In this review, we summarize the main pharmacological effects and pharmacological mechanisms of imidazothiazole derivates; the contents summarized herein are intended to advance the research and rational development of imidazothiazole-based drugs in the future.

Keywords: condensed heterocyclic compounds; druggable candidates; imidazothiazoles; levamisole; pharmacological effect.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest herein.

Figures

Figure 1
Figure 1
Chemical structures of (A) imidazole, thiazole and (B) imidazothiazole. (C) Studies on the pharmacological activity of imidazo[2,1-b]thiazoles.
Figure 2
Figure 2
Chemical structures of (A) compound 1 and (B) compound 2.
Figure 3
Figure 3
Chemical structures of (A) compound 3 and (B) compound 4.
Figure 4
Figure 4
Chemical structures of (A) compound 5 and (B) compound 6.
Figure 5
Figure 5
Chemical structures of (A) compound 7 and (B) compound 8.
Figure 6
Figure 6
Chemical structures of (A) compound 9, (B) compound 10, (C) compound 11 and compound 12. (D) The proposed potential levamisole treatment mechanisms in early SARS-CoV-2 infection. LVM, levamisole; PL-pro, papain-like protease.
Figure 7
Figure 7
Chemical structures of (A) compound 13, (B) compound 14, (C) compound 15, (D) compound 16, (E) compound 17 and (F) compound 18.
Figure 8
Figure 8
Chemical structures of (A) compound 19 and (B) compound 20.
Figure 9
Figure 9
Chemical structures of (A) compound 21, (B) compound 22, (C) compound 23, (D) compound 24, (E) compound 25 and (F) compound 26. (G) Compound 26 docked in the active site of murine COX-2. Hydrogen atoms of the amino acid residues have been removed to improve clarity (Left). Superimposition of compound 25 on the SC558 molecule (Right) (Adapted from [51]).
Figure 10
Figure 10
Chemical structures of (A) compound 27, compound 28, compound 29, compound 30 and (B) compound 31.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Nalwaya R., Sahai A., Chander S., Sharma M., Malik R., Sarsodia G. Synthesis, characterization, and pharmacological evaluation of benzothiopyran derivatives as a novel class of calcium channel blockers. Med. Chem. Res. 2013;22:2188–2195. doi: 10.1007/s00044-012-0211-y. - DOI
    1. Li Y., Bionda N., Fleeman R., Wang H., Ozawa A., Houghten R.A., Shaw L. Identification of 5,6-dihydroimidazo [2,1-b]thiazoles as a new class of antimicrobial agents. Bioorg. Med. Chem. 2016;24:5633–5638. doi: 10.1016/j.bmc.2016.09.027. - DOI - PMC - PubMed
    1. Verma A., Joshi S., Singh D. Imidazole: Having Versatile Biological Activities. J. Chem. 2013;2013:329412. doi: 10.1155/2013/329412. - DOI
    1. Salah A.M.B., Fendri L.B., Bataille T., Herrera R.P., Naïli H. Synthesis, structural determination and antimicrobial evaluation of two novel CoII and ZnII halogenometallates as efficient catalysts for the acetalization reaction of aldehydes. Chem. Cent. J. 2018;12:24. doi: 10.1186/s13065-018-0393-6. - DOI - PMC - PubMed
    1. Şenkardeş S., Kulabaş N., Bingöl Özakpinar Ö., Kalayci S., Şahin F., Küçükgüzel İ., Küçükgüzel Ş.G. Synthesis and Anticancer and Antimicrobial Evaluation of Novel Ether-linked Derivatives of Ornidazole. Turk. J. Pharm. Sci. 2020;17:81–93. doi: 10.4274/tjps.galenos.2018.59389. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources