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Review
. 2023 Jun 29;28(13):5082.
doi: 10.3390/molecules28135082.

Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review

Jiaying Cai  1   2   3 , Qichao Hu  4 , Zhelin He  5 , Xiaoyan Chen  5 , Jian Wang  5 , Xiang Yin  5 , Xiao Ma  4 , Jinhao Zeng  1   2   3
Affiliations
Review

Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review

Jiaying Cai et al. Molecules. .

Abstract

Ovarian cancer (OC) is one of the most common types of cancer in women with a high mortality rate, and the treatment of OC is prone to high recurrence rates and side effects. Scutellaria baicalensis (SB) is a herbal medicine with good anti-cancer activity, and several studies have shown that SB and its flavonoids have some anti-OC properties. This paper elucidated the common pathogenesis of OC, including cell proliferation and cell cycle regulation, cell invasion and metastasis, apoptosis and autophagy, drug resistance and angiogenesis. The mechanisms of SB and its flavonoids, wogonin, baicalein, baicalin, Oroxylin A, and scutellarein, in the treatment of OC, are revealed, such as wogonin inhibits proliferation, induces apoptosis, inhibits invasion and metastasis, and increases the cytotoxicity of the drug. Baicalein also inhibits vascular endothelial growth factor (VEGF) expression etc. Analyzing their advantages and disadvantages in treating OC provides a new perspective on the role of SB and its flavonoids in OC treatment. It serves as a resource for future OC research and development.

Keywords: Chinese medicine; Scutellaria baicalensis; flavonoid; ovarian cancer; pathogenesis.

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Conflict of interest statement

All authors declare no interest conflicts and agree to publish this paper.

Figures

Figure 1
Figure 1
Inhibitory effect of Scutellaria baicalensis and its natural compounds on ovarian cancer. Created by Biorender.com.
Figure 2
Figure 2
Pathogenesis of ovarian cancer. Created by Biorender.com.
Figure 3
Figure 3
Anti-ovarian cancer mechanism of Scutellaria baicalensis and its natural compounds. Created by Biorender.com.
See this image and copyright information in PMC

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