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. 2023 Jun 27;15(13):2912.
doi: 10.3390/nu15132912.

Therapeutic Potential of Bioactive Compounds from Brugmansia suaveolens Bercht. & J. Presl

Sandro Pinheiro da Costa  1 , Raphaela Aparecida Schuenck-Rodrigues  2 , Verônica da Silva Cardoso  3 , Simone Sacramento Valverde  4 , Alane Beatriz Vermelho  3 , Eduardo Ricci-Júnior  2
Affiliations

Therapeutic Potential of Bioactive Compounds from Brugmansia suaveolens Bercht. & J. Presl

Sandro Pinheiro da Costa et al. Nutrients. .

Abstract

Brugmansia suaveolens Bercht. & J. Presl has been widely used due to the presence of different bioactive compounds. This review summarizes the latest advances and perspectives of the B. suaveolens plant species; it is a systematic literature review on aspects of botany, traditional uses, phytochemistry, pharmacology, and toxicology as therapeutic potential. In addition, 120 compounds are described, including alkaloids, flavonoids, terpenoids, steroids, amino acids, aromatics, and aliphatics. As for the therapeutic potential, it is described in extracts and compounds in the antitumor, anti-inflammatory, antioxidant, antimicrobial, antispasmodic, anticoagulant, and analgesic aspects, as well as the effects on the central nervous system. The toxicity of the genus stands out, especially the potential for organ toxicity. Therefore, this review evidenced the knowledge related to the traditional use based on the scientific research of Brugmansia suaveolens, highlighting an overview of bioactive compounds and biological and toxicological activities in order to provide a scientific basis for future studies on the value of this species for the development of new natural products.

Keywords: Brugmansia suaveolens Bercht. & J. Presl; Solanaceae; therapeutic potential; tropane alkaloids.

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Conflict of interest statement

The authors declare no competing interest in this research. The authors declare no conflict of financial or non-financial interests that are directly or indirectly related to the paper submitted for publication.

Figures

Figure 1
Figure 1
Flowchart with the study selection steps adapted from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Figure 2
Figure 2
Compounds isolated and described in the B. suaveolens Bercht. & J. Presl plant species obtained, compiled as source data for the review.
Figure 3
Figure 3
Compounds isolated and described in the B. suaveolens Bercht. & J. Presl plant species obtained, compiled as source data for the review.
Figure 4
Figure 4
Frequency of the main parts of the B. suaveolens Bercht. & J. Presl plant species used for compound isolation studies and biological assays.
See this image and copyright information in PMC

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