Association of Pulmonary Function with Osteosarcopenic Obesity in Older Adults Aged over 50 Years

Abstract

Osteosarcopenic obesity (OSO) is a newly described coexistence of osteopenia/osteoporosis, sarcopenia, and obesity. We examined the association between pulmonary function, OSO, and its composition in adults aged ≥ 50 years. A total of 26,343 participants (8640 men; 17,703 women) were classified into four groups based on the number of abnormal body compositions (osteopenia/osteoporosis, sarcopenia, and obesity): 0 (control), 1+, 2+, and 3+ (OSO) abnormal body compositions. The values of forced volume vital capacity (FVC)%, forced expiratory volume in 1 s (FEV1%), and FEV1/FVC% were significantly decreased by increasing the number of adverse body compositions (p < 0.0001). Although the prevalence of restrictive spirometry pattern (RSP) was positively associated with a higher number of abnormal body composition parameters (p < 0.001), obstructive spirometry pattern (OSP) had no association with adverse body composition. In multivariate analyses, the adjusted odds ratios (ORs) for RSP compared to the control group were 1.36 in 1+, 1.47 in 2+, and 1.64 in 3+ abnormal body compositions (p for trend < 0.001). Multiple abnormal body composition, especially osteosarcopenic obesity, was independently associated with poor lung function showing RSP in older adults over 50 years. The coexistence of these abnormal body compositions may be a predisposing factor for pulmonary function deterioration.

Keywords: lung function; obesity; osteoporosis; osteosarcopenic obesity; sarcopenia.

Figure 1

Selection of Study Population.

Figure 2

Prevalence of restrictive spirometry pattern (A) and obstructive spirometry pattern (B) according to abnormal body compositions. Restrictive spirometry pattern: FEV1/FVC ≥ 70% and FVC < 80% predicted. Obstructive spirometry pattern: FEV1/FVC < 70% and FEV1 < 80% predicted. OSO, osteosarcopenic obesity.