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Review
. 2023 Jul 3;15(13):3022.
doi: 10.3390/nu15133022.

Therapeutic Activity of Green Tea Epigallocatechin-3-Gallate on Metabolic Diseases and Non-Alcoholic Fatty Liver Diseases: The Current Updates

Armachius James  1   2 , Ke Wang  1   3 , Yousheng Wang  1
Affiliations
Review

Therapeutic Activity of Green Tea Epigallocatechin-3-Gallate on Metabolic Diseases and Non-Alcoholic Fatty Liver Diseases: The Current Updates

Armachius James et al. Nutrients. .

Abstract

Green tea polyphenols have numerous functions including antioxidation and modulation of various cellular proteins and are thus beneficial against metabolic diseases including obesity, type 2 diabetes, cardiovascular and non-alcoholic fatty liver diseases, and their comorbidities. Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea and is attributed to antioxidant and free radical scavenging activities, and the likelihood of targeting multiple metabolic pathways. It has been shown to exhibit anti-obesity, anti-inflammatory, anti-diabetic, anti-arteriosclerotic, and weight-reducing effects in humans. Worldwide, the incidences of metabolic diseases have been escalating across all age groups in modern society. Therefore, EGCG is being increasingly investigated to address the problems. This review presents the current updates on the effects of EGCG on metabolic diseases, and highlights evidence related to its safety. Collectively, this review brings more evidence for therapeutic application and further studies on EGCG and its derivatives to alleviate metabolic diseases and non-alcoholic fatty liver diseases.

Keywords: EGCG; green tea; hyperglycemia; hyperuricemia; metabolic disease; non-alcoholic fatty liver disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Epigallocatechin-3-gallate (EGCG): a catechin ester of epigallocatechin and gallic acid with three aromatic rings linked by a pyran ring, which contributes to its functional benefits.
Figure 2
Figure 2
EGCG and metabolic syndrome, target the functioning of the gastrointestinal tract, the liver, the kidneys, and the heart. CVD: cardiovascular diseases and FXR: farnesoid X receptor.
Figure 3
Figure 3
EGCG targets various pathways and metabolic processes to alleviate non-alcoholic fatty liver disease (NAFLD): SCFA: shorty chain fatty acids, ROS: reactive oxygen species, AST: aspartate aminotransferase, ALT: alanine aminotransaminase, NF-κB: nuclear factor kappa B, TLR 4: toll-like receptor 4.
See this image and copyright information in PMC

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