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Review
. 2023 Jul 6;15(13):3055.
doi: 10.3390/nu15133055.

Looking for the Ideal Probiotic Healing Regime

Alexandra Menni  1 , Moysis Moysidis  1 , Georgios Tzikos  1 , George Stavrou  2 , Joulia K Tsetis  3 , Anne D Shrewsbury  1 , Eirini Filidou  4 , Katerina Kotzampassi  1
Affiliations
Review

Looking for the Ideal Probiotic Healing Regime

Alexandra Menni et al. Nutrients. .

Abstract

Wound healing is a multi-factorial response to tissue injury, aiming to restore tissue continuity. Numerous recent experimental and clinical studies clearly indicate that probiotics are applied topically to promote the wound-healing process. However, the precise mechanism by which they contribute to healing is not yet clear. Each strain appears to exert a distinctive, even multi-factorial action on different phases of the healing process. Given that a multi-probiotic formula exerts better results than a single strain, the pharmaceutical industry has embarked on a race for the production of a formulation containing a combination of probiotics capable of playing a role in all the phases of the healing process. Hence, the object of this review is to describe what is known to date of the distinctive mechanisms of each of the most studied probiotic strains in order to further facilitate research toward the development of combinations of strains and doses, covering the whole spectrum of healing. Eleven probiotic species have been analyzed, the only criterion of inclusion being a minimum of two published research articles.

Keywords: Bifidobacterium longum; Lacticaseibacillus casei; Lacticaseibacillus rhamnosus; Lactobacillus acidophilus; Lactobacillus fermentum; Lactoplantibacillus plantarum; Levilactobacillus brevis; Limosilactobacillus reuteri; Saccharomyces boulardi; wound healing.

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Conflict of interest statement

All authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The effect of probiotics on wound healing stages.
See this image and copyright information in PMC

References

    1. Gupta S., Poret A.J., Hashemi D., Eseonu A., Yu S.H., D’Gama J., Neel V.A., Lieberman T.D. Cutaneous Surgical Wounds Have Distinct Microbiomes from Intact Skin. Microbiol. Spectr. 2023;11:e0330022. doi: 10.1128/spectrum.03300-22. - DOI - PMC - PubMed
    1. Johnson T.R., Gómez B.I., McIntyre M.K., Dubick M.A., Christy R.J., Nicholson S.E., Burmeister D.M. The Cutaneous Microbiome and Wounds: New Molecular Targets to Promote Wound Healing. Int. J. Mol. Sci. 2018;19:2699. doi: 10.3390/ijms19092699. - DOI - PMC - PubMed
    1. Kotzampassi K., Kolios G., Manousou P., Kazamias P., Paramythiotis D., Papavramidis T.S., Heliadis S., Kouroumalis E., Eleftheriadis E. Oxidative stress due to anesthesia and surgical trauma: Importance of early enteral nutrition. Mol. Nutr. Food Res. 2009;53:770–779. doi: 10.1002/mnfr.200800166. - DOI - PubMed
    1. Munley J.A., Kelly L.S., Park G., Gillies G.S., Pons E.E., Kannan K.B., Whitley E.M., Bible L.E., Efron P.A., Nagpal R., et al. Multicompartmental traumatic injury induces sex-specific alterations in the gut microbiome. J. Trauma Acute Care Surg. 2023;95:30–38. doi: 10.1097/TA.0000000000003939. - DOI - PMC - PubMed
    1. Sorg H., Tilkorn D.J., Hager S., Hauser J., Mirastschijski U. Skin wound healing: An update on the current knowledge and concepts. Eur. Surg. Res. 2017;58:81–94. doi: 10.1159/000454919. - DOI - PubMed

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