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Review
. 2024;27(7):947-958.
doi: 10.2174/1386207326666230713125512.

A Review on the Mechanism and Structure-activity Relationship of Resveratrol Heteroaryl Analogues

Yijun Xiang  1 , Yao Xu  1 , Jiaxin Li  1 , Jingyi Jiang  1 , Yanjie Wang  1 , Xiaoshun Li  1 , Wenbin Ai  1 , Pengbing Mi  1 , Zehua Yang  1 , Zitong Zheng  1
Affiliations
Review

A Review on the Mechanism and Structure-activity Relationship of Resveratrol Heteroaryl Analogues

Yijun Xiang et al. Comb Chem High Throughput Screen. 2024.

Abstract

Resveratrol is one of the most interesting naturally-occurring nonflavonoid phenolic compounds with various biological activities, such as anticancer, neuroprotection, antibacterial, and anti-inflammatory. However, there is no clinical usage of resveratrol due to either its poor activity or poor pharmacokinetic properties. Heteroarenes-modified resveratrol is one pathway to improve its biological activities and bioavailability, and form more modification sites. In this review, we present the progress of heteroaryl analogues of resveratrol with promising biological activities in the latest five years, ranging from the synthesis to the structure-activity relationship and mechanism of actions. Finally, introducing heteroarenes into resveratrol is an effective strategy, which focuses on the selectivity of structure-activity relationship in vivo.

Keywords: NPs.; Resveratrol analogues; bioactivity; heteroarenes; heteroaromatic rings; structure-activity relationship.

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References

    1. Baur J.A.; Sinclair D.A.; Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Discov 2006,5(6),493-506 - DOI - PubMed
    1. Sales J.M.; Resurreccion A.V.A.; Resveratrol in peanuts. Crit Rev Food Sci Nutr 2014,54(6),734-770 - DOI - PubMed
    1. Jeandet P.; Bessis R.; Gautheron B.; The production of resveratrol (3,5,4′-trihydroxystilbene) by grape berries in difffferent developmental stages. Am J Enol Vitic 1991,42(1),41-46 - DOI
    1. Lyons M.M.; Yu C.; Toma R.B.; Cho S.Y.; Reiboldt W.; Lee J.; van Breemen R.B.; Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem 2003,51(20),5867-5870 - DOI - PubMed
    1. Dai M.; Yuan D.; Lei Y.; Li J.; Ren Y.; Zhang Y.; Cang H.; Gao W.; Tang Y.; Expression, purification and structural characterization of resveratrol synthase from polygonum cuspidatum. Protein Expr Purif 2022,191,106024 - DOI - PubMed

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