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Case Reports
. 2023 May-Jun;33(3):206-208.
doi: 10.4103/ijn.ijn_187_21. Epub 2023 Feb 20.

A Case of Posttransplant Fibrillary Glomerulonephritis

Shiva Kumar Ammayappan  1 , Arul Rajagopalan  1 , Manorajan Rajendran  1 , Jegan Arunachalam  1 , Arun Prasath  1 , Rakesh Durai  1 , Anila A Kurien  2
Affiliations
Case Reports

A Case of Posttransplant Fibrillary Glomerulonephritis

Shiva Kumar Ammayappan et al. Indian J Nephrol. 2023 May-Jun.

Abstract

Fibrillary glomerulonephritis (FGN) is a rare form of glomerulonephritis, usually occurring in concurrence with other conditions such as hepatitis C, dysproteinemia, autoimmune conditions, diabetes mellitus, and malignancy. The diagnosis is made by the presence of randomly oriented fibrillar deposits with a mean diameter of 20 nm, which stain positive for IgG and C3 and are negative for congo red and thioflavin T stains. Staining for DNAJB9 (DnaJ homolog subfamily B member 9) is a recently discovered mode of diagnosis of FGN without electron microscopy. The prognosis is poor and optimal treatment is yet not clearly defined, though rituximab may be useful in FGN patients with relatively preserved renal functions. In this case report, we discuss a case of post-renal transplant patient with de novo occurrence of fibrillary glomerulonephritis.

Keywords: Fibrillary GN; glomerulonephritis; posttransplant.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Hematoxylin and eosin stain and PASM (periodic Schiff methenamine) stain
Figure 2
Figure 2
Immunofluorescence for IgG and DNAJB9 stain
See this image and copyright information in PMC

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