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. 2023 Jun 24:14:100336.
doi: 10.1016/j.jvacx.2023.100336. eCollection 2023 Aug.

Diabetes incidence before and after COVID-19 vaccination - Results from the German Disease Analyzer database

Bernd Kowall  1 , Karel Kostev  2 , Rüdiger Landgraf  3 , Hans Hauner  4 , Ralf Bierwirth  5 , Oliver Kuss  6   7 , Wolfgang Rathmann  6
Affiliations

Diabetes incidence before and after COVID-19 vaccination - Results from the German Disease Analyzer database

Bernd Kowall et al. Vaccine X. .

Abstract

Objective: We investigated whether COVID-19 vaccination had an impact on diabetes risk.

Methods: We used data of 6,198 patients (mean age 64.3 years) from the nationwide Disease Analyzer database, a representative panel of physicians' practices in Germany. Patients received their first COVID-19 vaccination between 1 April 2021 and 31 March 2022, and all were newly diagnosed with diabetes within 183 days before or after this vaccination. Incident rates of diabetes after vaccination were compared to incident rates before vaccination.

Results: The incidence rate of diabetes was lower after vaccination than before vaccination (incidence rate ratio = 0.79, 95% confidence interval: 0.75-0.83). The number of incident cases of diabetes was not greater in 2021 than in 2019.

Conclusion: Our study did not confirm an increased risk of diabetes after COVID-19 vaccination. Further studies are needed to show whether the vaccination may be associated with a reduced diabetes risk.

Keywords: COVID-19; Diabetes mellitus; SARS-CoV-2; Vaccination.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Overall monthly numbers of incident cases of diabetes in 970 practices (2021 vs 2019): the German Disease Analyzer database. The numbers refer to all patients with newly diagnosed diabetes in the 970 practices irrespective of vaccination.
See this image and copyright information in PMC

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