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. 2023 Dec;18(12):2691-2692.
doi: 10.4103/1673-5374.373712.

Implication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease

Cristina Municio  1 , Eva Carro  2
Affiliations

Implication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease

Cristina Municio et al. Neural Regen Res. 2023 Dec.
No abstract available

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Schematic representation of the entry of Porphyromonas gingivalis (P. gingivalis) to the CNS. In healthy conditions, P. gingivalis population is under control in oral cavity. After dysregulation of the oral microbioma, P. gingivalis invades and colonizes the oral cavity. (A) Production of OMV after the bacterial cell wall is excised. OMV are enrichment in outer membrane proteins, lipoproteins, and extracellular components from P. gingivalis. (B) P. gingivalis and OMVs after entering in cerebral endothelial cells, through the blood circulation. Gingipains increase the permeability of the BBB and the choroid plexus epithelial cells due to degradation of tight junction proteins as occludin or ZO1. BBB: Brain-blood barrier; CNS: central nervous system; LPS: lipopolysaccharide; OMV: outer membrane vesicle; ZO1: zonula occludens. Created by the authors with PowerPoint and Canva.com.
Figure 2
Figure 2
Flowchart showing lactoferrin-mediated antimicrobial activities in healthy and AD conditions. AD: Alzheimer’s disease; AMPs: antimicrobial peptides; BBB: brain-blood barrier; LF: lactoferrin. Created by the authors with Canva.com.
See this image and copyright information in PMC

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