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Review
. 2023 Nov 2;54(6):e177-e185.
doi: 10.1093/labmed/lmad060.

Plasmablastic transformation of chronic lymphocytic leukemia: a review of literature and report on 2 cases

Anurag Khanna  1 , Bradley R Drumheller  1 , George Deeb  1 , Ethan Wade Tolbert  2 , Saja Asakrah  1
Affiliations
Review

Plasmablastic transformation of chronic lymphocytic leukemia: a review of literature and report on 2 cases

Anurag Khanna et al. Lab Med. .

Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common leukemia in adults in Western countries. Transformation of CLL/SLL to plasmablastic lymphoma (PBL) is exceedingly rare and often has an extremely poor response to treatment. A thorough molecular workup may help in determining clonality-relatedness and prognosis. We describe two cases of CLL/SLL that transformed into PBL, with an extensive molecular workup in one case, and a review of the literature.

Keywords: EBV infected lymphoma cells; chronic lymphocytic leukemia; clonality relatedness; mutational analysis; plasmablastic transformation.

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