Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023:2695:317-335.
doi: 10.1007/978-1-0716-3346-5_22.

Potential Value and Application of Liquid Biopsy in Tumor, Neurodegeneration, and Muscle Degenerative Diseases

Lin Chen  1 , Jun Yang  2 , Guodong Xu  1 , Yuxiang Wu  3
Affiliations
Review

Potential Value and Application of Liquid Biopsy in Tumor, Neurodegeneration, and Muscle Degenerative Diseases

Lin Chen et al. Methods Mol Biol. 2023.

Abstract

Liquid biopsy provides a promising alternative for the detection of disease-specific markers due to its superior noninvasive and original tissue representativeness. Liquid biopsies have a wide range of health and disease applications involving components ranging from circulating cells to acellular nucleic acid molecules and other metabolites. Here, we review the different components of liquid biopsy and investigate the most advanced noninvasive methods for detecting these components as well as their existing problems and trends. In particular, we emphasize the importance of analyzing liquid biopsy data from extracellular vesicles and small nucleic acids in neurological and muscle degeneration, with the aim of using this technique to enhance personalized healthcare. Although previous reviews have focused on cancer, this review mainly emphasizes the potential application of extracellular vesicles and microRNAs in liquid biopsy in neurodegeneration and muscle degeneration.

Keywords: Extracellular vesicle; Liquid biopsy; MicroRNA; Muscle degeneration; Neurodegeneration.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Marquette CH et al (2020) Circulating tumour cells as a potential biomarker for lung cancer screening: a prospective cohort study. Lancet Respir Med 8(7):709–716 - PubMed - DOI
    1. Heitzer E et al (2019) Current and future perspectives of liquid biopsies in genomics-driven oncology. Nat Rev Genet 20(2):71–88 - PubMed - DOI
    1. Doval DC et al (2017) Liquid biopsy: a potential and promising diagnostic tool for advanced stage non-small cell lung cancer patients. Indian J Cancer 54(Supplement):S25–S30 - PubMed - DOI
    1. Rolfo C et al (2018) Liquid biopsy for advanced non-small cell lung cancer (NSCLC): a statement paper from the IASLC. J Thorac Oncol 13(9):1248–1268 - PubMed - DOI
    1. Jacobson RA et al (2019) Evolving clinical utility of liquid biopsy in gastrointestinal cancers. Cancers (Basel) 11(8):1164 - PubMed - DOI

Publication types

MeSH terms

Substances

LinkOut - more resources