Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023:2695:351-365.
doi: 10.1007/978-1-0716-3346-5_24.

Advances of Liquid Biopsy for Diagnosis of Atrial Fibrillation and Its Recurrence After Ablation in Clinical Application

Lingtong Shan  1 , Jiapeng Chen  2 , Yangyang Sun  3 , Yilin Pan  3 , Chong Wang  4 , Yuliang Wang  5 , Yangyang Zhang  4
Affiliations
Review

Advances of Liquid Biopsy for Diagnosis of Atrial Fibrillation and Its Recurrence After Ablation in Clinical Application

Lingtong Shan et al. Methods Mol Biol. 2023.

Abstract

Atrial fibrillation (AF) is a common arrhythmia disease with high morbidity in clinical practice and leads to stroke, heart failure, peripheral embolism, and other severe complications. With aging of the society, AF has become one of the biggest public health challenges. Effective treatments including antiarrhythmic drugs, electrical cardioversion, and ablation (with or without catheters) can alleviate the symptoms of AF. Ablation is the most effective method for the treatment of persistent AF, but cannot cure all patients. Recurrence of AF is a realistic and unavoidable problem. For early predicting and warning of AF and its recurrence, liquid biopsy for accurate molecular analysis of biofluids is a new strategy with potential value and easy sampling and can detect genetic and epigenetic polymorphisms, especially microRNAs. In this review, liquid biopsy is constructed as a new powerful way for diagnosing AF and predicting its recurrence, contributing to the treatment of AF.

Keywords: Ablation; Atrial fibrillation; Liquid biopsy; Recurrence.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Lippi G, Sanchis-Gomar F, Cervellin G (2021) Global epidemiology of atrial fibrillation: an increasing epidemic and public health challenge. Int J Stroke 16(2):217–221 - PubMed - DOI
    1. Benjamin EJ, Muntner P, Alonso A et al (2019) Heart disease and stroke Statistics-2019 update: a report from the American Heart Association. Circulation 139(10):e56–e528 - PubMed - DOI
    1. Amuthan R, Curtis AB (2021) What clinical trials of ablation for atrial fibrillation tell us – and what they do not. Heart Rhythm O2 2(2):174–186 - PubMed - PMC - DOI
    1. Zink MD, Chua W, Zeemering S et al (2020) Predictors of recurrence of atrial fibrillation within the first 3 months after ablation. Europace 22(9):1337–1344 - PubMed - PMC - DOI
    1. Shah S, Barakat AF, Saliba WI et al (2018) Recurrent atrial fibrillation after initial long-term ablation success: electrophysiological findings and outcomes of repeat ablation procedures. Circ Arrhythm Electrophysiol 11(4):e005785 - PubMed - DOI

Substances

LinkOut - more resources