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. 2023 Aug 8;330(6):561-563.
doi: 10.1001/jama.2023.12945.

Monoclonal Antibody and Oral Antiviral Treatment of SARS-CoV-2 Infection in US Nursing Homes

Brian E McGarry  1 , Benjamin D Sommers  2 , Andrew D Wilcock  3 , David C Grabowski  3 , Michael L Barnett  2
Affiliations

Monoclonal Antibody and Oral Antiviral Treatment of SARS-CoV-2 Infection in US Nursing Homes

Brian E McGarry et al. JAMA. .
No abstract available

Plain language summary

This study examines the use of COVID-19 antiviral treatments in US nursing homes and the facility characteristics associated with use of oral antivirals and monoclonal antibodies.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr McGarry reported receiving grant support from the National Institute on Aging (NIA) and the Agency for Healthcare Research and Quality during the conduct of this study and receiving consulting fees from AARP outside the submitted work. Dr Sommers reported receiving grants from NIA (R01 AG075507) during the conduct of the study; receiving grants from the Commonwealth Fund, Robert Wood Johnson Foundation, and Jameel Poverty Action Lab; receiving consulting fees from the Illinois Department of Healthcare and Family Services outside the submitted work; and serving in the US Department of Health and Human Services (HHS) from January 2021 to January 2023 and continuing to serve in a part-time role in spring 2023. Dr Grabowski reported receiving consulting fees from AARP, Analysis Group, GRAIL, LLC, and the Medicare Payment Advisory Commission outside the submitted work. Dr Barnett reported receiving consulting fees from the California Department of Health Care Services outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Oral Antiviral or Monoclonal Antibody Use for COVID-19 in US Nursing Homes
A, Data from the National Healthcare Safety Network (NHSN) database from 15 092 nursing homes. B, Moving 6-week average of Winsorized weekly treatment rates. Monoclonal antibodies include bamlanivimab, casirivimab plus imdevimab, bamlanivimab plus etesevimab, sotrovimab, and bebtelovimab. The NHSN data do not contain information on the use of remdesivir.
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References

    1. Centers for Medicare & Medicaid Services . COVID-19 nursing home data. Published 2023. Updated June 25, 2023. Accessed March 22, 2023. https://data.cms.gov/covid-19/covid-19-nursing-home-data
    1. Department of Health and Human Services . Winter playbook for nursing homes and other long-term care facilities to manage COVID-19 and protect residents, staff, and visitors. Published 2022. Accessed May 17, 2023. https://www.whitehouse.gov/wp-content/uploads/2022/12/Winter-Playbook-fo...
    1. Murphy SJ, Samson LW, Sommers BD. COVID-19 antivirals utilization: geographic and demographic patterns of treatment in 2022. Office of the Assistant Secretary for Planning and Evaluation. Published December 23, 2022. Accessed May 11, 2023. https://aspe.hhs.gov/reports/covid-19-antivirals-utilization
    1. Tulledge-Scheitel S, Bell SJ, Larsen JJ, et al. A mobile unit overcomes the challenges to monoclonal antibody infusion for COVID-19 in skilled care facilities. J Am Geriatr Soc. 2021;69(4):868-873. doi: 10.1111/jgs.17090 - DOI - PMC - PubMed
    1. Kip KE, McCreary EK, Collins K, et al. Evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19: a cohort study. Ann Intern Med. 2023;176(4):496-504. doi: 10.7326/M22-1286 - DOI - PMC - PubMed

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