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. 1979 Apr;4(2):223-39.
doi: 10.1007/BF00964146.

The role of thiamine in nervous tissue

J R Cooper, J H Pincus

The role of thiamine in nervous tissue

J R Cooper et al. Neurochem Res. 1979 Apr.

Abstract

The possibility that thiamine (vitamin B1) has a role in nervous tissue that is independent of its well-documented coenzyme function is discussed. After reviewing the localization and metabolism of the vitamin and its phosphate esters, the effects of either thiamine deprivation or antimetabolites of thiamine on conduction and transmission, and the relationship between thiamine triphosphate and the genetic, neurological disease, subacute necrotizing encephalomyelopathy (Leigh's disease), it is suggested that despite the lack of hard evidence, it is likely that the vitamin possesses this alternate function.

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