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Editorial
. 2023 Jul 14;14(7):429.
doi: 10.1038/s41419-023-05950-6.

Cyclin-dependent kinases regulate the adult nervous system via the one-carbon-metabolism

Alessia Angelin  1
Affiliations
Editorial

Cyclin-dependent kinases regulate the adult nervous system via the one-carbon-metabolism

Alessia Angelin. Cell Death Dis. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1. Cyclin-dependent kinases regulate the adult nervous system via the one-carbon metabolism.
Knockout CDK12 directly affects the formation of the adult nervous system, see for details Townsend et al. [7], via the one-carbon-metabolism. the one-carbon-metabolism consists of two modules, the folate and the methionine cycles. Folic acid is imported into cells and reduced to tetrahydrofolate (THF), before being converted to 5,10-methylene-THF (me-THF) by serine-hydroxymethyl-transferase (SHMT), and then reduced to 5-methyl-THF (mTHF) by methylene-THF-reductase (MTHFR) or converted into 10-formyl-THF (F-THF). mTHF is demethylated to close the folate cycle, and, more importantly, donating one carbon into the methyonine cycle via the methylation of homocysteine (hCYS) by the methionine synthase that uses vitamine B12 as cofactor, thus forming methionine (MET). MET, via the MET-adenyltransferase (MAT), generates S-adenosylmethionine (SAM), which, in turn, is demethylated into S-adenosylhomocysteine (SAH). Then, SAH-hydrolase (SAHH), converts SAH into hCYS, closing the cycle. The one-carbon-metabolism can be connected to the trans-sulfuration pathway, generating cystathionine, and, in turn, either a-ketobutyrate (aKB) or glutathione. (Created with Biorender.com).
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