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. 2023 Jul 14;13(1):11408.
doi: 10.1038/s41598-023-37766-x.

Identification of appropriate biochemical parameters and cut points to detect Maturity Onset Diabetes of Young (MODY) in Asian Indians in a clinic setting

Ramasamy Aarthy  1   2 , Kathryn Aston-Mourney  2 , Anandakumar Amutha  1 , Antonina Mikocka-Walus  3 , Ranjit Mohan Anjana  1   4 , Ranjit Unnikrishnan  1   4 , Saravanan Jebarani  1 , Ulagamathesan Venkatesan  1 , Sundaramoorthy Gopi  1 , Venkatesan Radha  1 , Viswanathan Mohan  5   6
Affiliations

Identification of appropriate biochemical parameters and cut points to detect Maturity Onset Diabetes of Young (MODY) in Asian Indians in a clinic setting

Ramasamy Aarthy et al. Sci Rep. .

Abstract

Maturity Onset Diabetes of the Young (MODY) is a monogenic form of diabetes which is detected by genetic testing. We looked at clinical and biochemcial variables that could help detect possible MODY among Asian Indians with youth-onset diabetes. From the diabetes electronic medical records of a diabetes care centre in Chennai in southern India, demographic, anthropometric, and biochemical details of 34 genetically confirmed MODY participants were extracted. They were compared with patients with type 1 diabetes (T1D) (n = 1011) and type 2 diabetes (T2D) (n = 1605), diagnosed below 30 years of age. Clinical and biochemical variables including body mass index (BMI), glycated hemoglobin, HDL cholesterol, and C-peptide (fasting and stimulated) were analyzed to determine whether cut points could be derived to identify individuals who could be sent for genetic testing to diagnose or rule out MODY in this ethnic group. The age at diagnosis was higher for T2D (26.5 ± 4.0 years) compared to T1D (18.2 ± 6.1 years) and MODY (17.8 ± 6.0 years). Individuals with MODY had BMI, glycated hemoglobin, total cholesterol, triglycerides, HDL cholesterol, and C-peptide levels which were intermediate between T1D and T2D. The identified probable parameters and their cut points to identify cases for MODY genetic screening were BMI 21.2-22.7 kg/m2, glycated hemoglobin 7.2-10%, HDL cholesterol 43-45 mg/dl, fasting C -peptide, 1.2-2.1 ng/ml and stimulated C-peptide, 2.1-4.5 ng/ml. Asian Indians with MODY have clinical features that are intermediate between T1D and T2D and selected biochemical parameters, especially stimulated C peptide cut points were the most useful to diagnose MODY.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
(a)–(f) Density plots for T1D, T2D and MODY.
Figure 2
Figure 2
(a)–(e) ROC curves for T1D versus MODY.
Figure 3
Figure 3
(a)–(e) ROC curves for T2D versus MODY.
See this image and copyright information in PMC

References

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Publication types

Supplementary concepts