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Review
. 2023 Oct;24(10):e13603.
doi: 10.1111/obr.13603. Epub 2023 Jul 14.

Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks

Tahir Muhammad  1   2   3   4   5   6 , Yanling Wan  1   2   3   4 , Yue Lv  7   8 , Hanzhen Li  1   2   3   4 , Wasifa Naushad  9 , Wai-Yee Chan  1   2   4   8 , Gang Lu  1   2   4   8 , Zi-Jiang Chen  1   2   3   4   7   8   10   11 , Hongbin Liu  1   2   3   4   8   10
Affiliations
Review

Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks

Tahir Muhammad et al. Obes Rev. 2023 Oct.

Abstract

Currently, obesity has achieved epidemic levels in reproductive-aged women with a myriad of consequences. Obesity is susceptible to several reproductive complications that eventually affect fertility rates. These complications originate from the deteriorated quality of oocytes from mothers with obesity, which increases the probability of chromosomal aneuploidy, elevated reactive oxygen species production, compromised embryonic developmental competency, and eventually reduced fertility. Maternal obesity is linked to pregnancy complications such as implantation error, abortion, miscarriage, and early pregnancy loss. This review highlights the adverse effects of maternal obesity on female fertility, with a focus on the mechanistic link between maternal obesity and oocyte quality and discusses possible measures to reduce its associated risks.

Keywords: infertility; obesity; oocyte quality; oxidative stress.

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References

REFERENCES

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