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Meta-Analysis
. 2023 Sep;10(9):5975-5988.
doi: 10.1002/nop2.1902. Epub 2023 Jul 14.

Adverse effects of dorsogluteal intramuscular injection versus ventrogluteal intramuscular injection: A systematic review and meta-analysis

María Teresa Roldán-Chicano  1   2 , Javier Rodríguez-Tello  1 , Raquel Cebrián-López  1 , James Richard Moore  3 , María Del Mar García-López  4
Affiliations
Meta-Analysis

Adverse effects of dorsogluteal intramuscular injection versus ventrogluteal intramuscular injection: A systematic review and meta-analysis

María Teresa Roldán-Chicano et al. Nurs Open. 2023 Sep.

Abstract

Aims: To determine adverse effects of ventrogluteal intramuscular injections versus dorsogluteal intramuscular injections.

Design: A systematic review and meta-analysis.

Methods: MEDLINE, EMBASE, CINHAL, CENTRAL, LILACS(BVS), BDENF (BVS), WoS, IRCTP(WHO), ClinicalsTrials.gov and PROSPERO databases were searched with no restriction on year or language. Preferred Reporting items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed.

Results: A total of 1429 participants from 17 studies were included. The meta-analysis found that ventrogluteal injection site had significant relation to lower pain in 9 studies (SMD = -0.63, 95% CI = -0.87, -0.39), bleeding in 4 studies (SMD = -3.46, 95% CI = -6.07, -0.86) and hematoma in 2 studies; after 48 h (SMD = -0.25, 95% CI = -0.39, -0.11), and after 72 h (SMD = -0.16, 95% CI = -0.26, -0.06), if it was compared with dorsogluteal site injection. No differences were found when comparing the possibility of intramuscular injections given into de subcutaneous tissue. In three studies, ventrogluteal site did not significantly reduce the risk of subcutaneous injection (OR 0,62, 95% CI = 0.16, 2.41).

Keywords: adverse effects; buttocks; dorsogluteal; injections; intramuscular; intramuscular/adverse effects*; intramuscular/methods*; nursing; subcutaneous; systematic review; ventrogluteal.

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Conflict of interest statement

The authors declare that they have no conflict of interest in relation to this work.

Figures

FIGURE 1
FIGURE 1
PRISMA 2020 flow diagram.
FIGURE 2
FIGURE 2
Funnel plot, publication vias.
FIGURE 3
FIGURE 3
Forest plot mean difference (MD) of subcutaneous adipose tissue.
FIGURE 4
FIGURE 4
Forest plot standardised mean difference (MD) of pain.
FIGURE 5
FIGURE 5
Forest plot, subgroup analysis of additional methods to reduce pain.
FIGURE 6
FIGURE 6
Forest plot, subgroup analysis of drugs administrated on pain.
FIGURE 7
FIGURE 7
Forest plot standardised mean difference (MD) of bleeding.
See this image and copyright information in PMC

References

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