Effects of platelet-rich fibrin and dexamethasone on nerve regeneration after acute facial-nerve injury

Abstract

Background: Acute facial-nerve injury.

Objective: To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration.

Materials and methods: Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks.

Results: The mean eye-closure movement score in Group B was significantly higher than that in Group F (p < .001). The mean whisker-movement score in Group B was significantly higher than that in Group F (p = .001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E (p < .001). Furthermore, an improvement in nerve ultrastructure was observed in Group B.

Conclusion: PRF application has a positive effect on nerve recovery after anastomosis.

Significance: Contribute to the literature to improve nerve regeneration.

Keywords: Dexamethasone; facial nerve; nerve recovery; platelet-rich fibrin.