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Review
. 2023 Sep;58(9):801-833.
doi: 10.1007/s00535-023-02014-6. Epub 2023 Jul 15.

Evidence-based clinical practice guidelines for cholelithiasis 2021

Naotaka Fujita  1   2 , Ichiro Yasuda  3 , Itaru Endo  3 , Hiroyuki Isayama  3 , Takuji Iwashita  3 , Toshiharu Ueki  3 , Kenichiro Uemura  3 , Akiko Umezawa  3 , Akio Katanuma  3 , Yu Katayose  3 , Yutaka Suzuki  3 , Junichi Shoda  3 , Toshio Tsuyuguchi  3 , Toshifumi Wakai  3 , Kazuo Inui  3 , Michiaki Unno  3 , Yoshifumi Takeyama  3 , Takao Itoi  3 , Kazuhiko Koike  3 , Satoshi Mochida  3
Affiliations
Review

Evidence-based clinical practice guidelines for cholelithiasis 2021

Naotaka Fujita et al. J Gastroenterol. 2023 Sep.

Abstract

The Japanese Society of Gastroenterology first published evidence-based clinical practice guidelines for cholelithiasis in 2010, followed by a revision in 2016. Currently, the revised third edition was published to reflect recent evidence on the diagnosis, treatment, and prognosis of cholelithiasis conforming to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Following this revision, the present English version of the guidelines was updated and published herein. The clinical questions (CQ) in the previous version were reviewed and rearranged into three newly divided categories: background questions (BQ) dealing with basic background knowledge, CQ, and future research questions (FRQ), which refer to issues that require further accumulation of evidence. Finally, 52 questions (29 BQs, 19 CQs, and 4 FRQs) were adopted to cover the epidemiology, pathogenesis, diagnosis, treatment, complications, and prognosis. Based on a literature search using MEDLINE, Cochrane Library, and Igaku Chuo Zasshi databases for the period between 1983 and August 2019, along with a manual search of new information reported over the past 5 years, the level of evidence was evaluated for each CQ. The strengths of recommendations were determined using the Delphi method by the committee members considering the body of evidence, including benefits and harms, patient preference, and cost-benefit balance. A comprehensive flowchart was prepared for the diagnosis and treatment of gallbladder stones, common bile duct stones, and intrahepatic stones, respectively. The current revised guidelines are expected to be of great assistance to gastroenterologists and general physicians in making decisions on contemporary clinical management for cholelithiasis patients.

Keywords: Cholelithiasis; Common bile duct stones; Endoscopic treatment; Gallbladder stones; Intrahepatic stones; Surgical treatment.

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Conflict of interest statement

Any financial relationship with enterprises, businesses or academic institutions in the subject matter or materials discussed in the manuscript are listed as follows: (1) those from which the authors, the spouse, partner or immediate relatives of the authors have received individually any income, honoraria or any other type of renumeration; Asahi Kasei Pharma, Olympus Corporation, Daiichi Sankyo, Fuji Film, Taiho Pharmaceutical, Denka, and (2) those from which the authors have received scholarship/research grant; Taiho Pharmaceutical, Tsumura & Co., Bristol Myers Squibb, Ajimonoto, Hitachi, Boston Scientific Japan, Denka, Hospital Administration Niigata Prefecture, Brourbon, Yasuda Yogurt, Astellas Pharmaceutical, Abbvie, EA Pharma, Eisai, MSD, Ono Pharmaceutical, Covidien Japan, Taiho Pharmaceutical, Takeda Pharmaceutical, Chugai Pharmaceutical, Novaltis Japan, Bayer Japan, Asahi Kasei Pharma, Nippon Kayaku, Mochida Pharmaceutical, Eli Lilly Japan, Gadelius Medical, Boston Scientific Japan, JRA Facilities, and (3) those from which the academic institutions of the authors received support (commercial/academic cooperation); Eisai.

Figures

Fig. 1
Fig. 1
Flowchart for diagnosis of gallbladder stones
Fig. 2
Fig. 2
Flowchart for diagnosis of acute cholecystitis
Fig. 3
Fig. 3
Flowchart for diagnosis of common bile duct stones
Fig. 4
Fig. 4
Flowchart for diagnosis of hepatolithiasis
Fig. 5
Fig. 5
Flowchart for treatment of gallbladder stones
Fig. 6
Fig. 6
Flowchart for treatment of common bile duct stones
Fig. 7
Fig. 7
a Flowchart for treatment of hepatolithiasis with previous choledochoenterostomy. b Flowchart for treatment of hepatolithiasis without previous choledochoenterostomy
See this image and copyright information in PMC

Comment in

References

    1. Tazuma S, Unno M, Igarashi Y, et al. Evidence-based clinical practice guidelines for cholelithiasis 2016. J Gastroenterol. 2017;52:276–300. doi: 10.1007/s00535-016-1289-7. - DOI - PubMed
    1. Minds Manual Developing Committee. Minds Manual for Guideline Development 2017. Tokyo: Japan Council for Quality Health Care; 2017. (in Japanese)
    1. Qaseem A, Kansagara D, Lin JS, et al. The Development of Clinical Guidelines and Guidance Statements by the Clinical Guidelines Committee of the American College of Physicians: Update of Methods. Ann Intern Med. 2019;170:863–870. doi: 10.7326/M18-3290. - DOI - PubMed
    1. Yoshida M, Kinoshita Y, Watanabe M, et al. JSGE Clinical Practice Guidelines 2014: standards, methods, and process of developing the guidelines. J Gastroenterol. 2015;50:4–10. doi: 10.1007/s00535-014-1016-1. - DOI - PubMed
    1. Health Statistics Association of Japan. Estimated number of patients based on patient surveys. Index of Health. 1993;39:29–35 (in Japanese).

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