Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep:169:105608.
doi: 10.1016/j.fitote.2023.105608. Epub 2023 Jul 13.

A novel skeleton alkaloid from Portulaca oleracea L. and its bioactivities

Xiujuan Lan  1 , Shengnan Guo  1 , Yingdai Zhao  1 , Mingbo Zhang  1 , Dinglin Zhang  2 , Aijing Leng  3 , Xixiang Ying  4
Affiliations

A novel skeleton alkaloid from Portulaca oleracea L. and its bioactivities

Xiujuan Lan et al. Fitoterapia. 2023 Sep.

Abstract

A novel skeleton alkaloid was obtained from Portulaca oleracea L., which was identified as 10,11-dihydroxybenzo[5',6'] pentaleno[1',2':3,4]pyrrolo[2,1-b]oxazol-7(11bH)-one, named oleracone M, and its structure was determined using UHPLC-ESI-QTOF/MS, 1D NMR and 2D NMR spectroscopy, and circular dichroism. Then the bioactivities of the compound were investigated including the anti-inflammatory, anti-acetylcholinesterase and antioxidant activities. The results showed that the novel skeleton alkaloid exhibited the potent effect on inhibiting the secretion of IL-1β at 10 μM, anticholinesterase activity with IC50 value of 49.58 μM, and antioxidant activity with IC50 value of 66.43 μM.

Keywords: Alkaloid; Anti-acetylcholinesterase activity; Antioxidant activity; IL-1β; Portulaca oleracea L..

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.