Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep;54(3):1745-1750.
doi: 10.1007/s42770-023-01067-2. Epub 2023 Jul 16.

Human T-lymphotropic virus 2 (HTLV-2) prevalence of blood donors in the state of Pará, Brazil

Lucas Pinheiro Correa  1 , Fatyene da Costa Farias  2 , Katarine Antonia Dos Santos Barile  2   3 , Maurício Koury Palmeira  2   3 , Carlos Eduardo de Melo Amaral  2   3
Affiliations

Human T-lymphotropic virus 2 (HTLV-2) prevalence of blood donors in the state of Pará, Brazil

Lucas Pinheiro Correa et al. Braz J Microbiol. 2023 Sep.

Abstract

Introduction: The present study had the objective to describe the molecular prevalence and epidemiological aspects of the human T-lymphotropic virus 2 (HTLV-2) infection in the blood donor population of the Pará state.

Methods: The present study is a descriptive, retrospective, and cross-sectional review of epidemiological, serological, and molecular data on inapt blood donors in the State Center for Hematology and Hemotherapy from January 2015 to December 2021. The data were digitalized to create a database using the Statistical Package for Social Sciences program. The prevalence of HTLV-2 was calculated based on the total number of donations during the study period. Descriptive frequency was used to analyze the qualitative data.

Results: A total of 665,568 blood donations were made. Out of these, 1884 (0.2%) samples presented serological detection to HTLV and further were evaluated using molecular confirmatory tests. Out of these, 36 samples were positive for HTLV-2 using qPCR Taqman assay based on pol gene region (0.005%). The HTLV-2 was found to be more prevalent in women (63.9%); aged between 39 and 59 years (55.6%); residents of the metropolitan region of Belém (80.6%); with self-declared race as brown (80.6%); individuals who had completed high school (58.6%); and first-time donors (58.3%) CONCLUSION: The present study identified the presence of HTLV-2 (1 HTLV-2 case/20,000 donations; 0.005%) in the specific population of blood donors in Pará state. These findings can contribute to the existing literature on the subject both for specific population groups under study and for understanding the prevalence of HTLV-2 in the general population.

Keywords: Blood bank; Blood donors; HTLV-2; Molecular epidemiology; Prevalence.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. Futsch N, Mahieux R, Dutartre H. HTLV-1, the other pathogenic yet neglected human retrovirus: from transmission to therapeutic treatment. Viruses. 2017;10(1):1. doi: 10.3390/v10010001. - DOI - PMC - PubMed
    1. González-Alcaide G, Ramos JM, Huamaní C, Mendoza C, Soriano V. human t-lymphotropic virus 1 (htlv-1) and human t-lymphotropic virus 2 (htlv-2): geographical research trends and collaboration networks (1989-2012) Rev Inst Med Trop Sao Paulo. 2016;58:11. doi: 10.1590/S1678-9946201658011. - DOI - PMC - PubMed
    1. Martinez MP, Al-Saleem J, Green PL. Comparative virology of HTLV-1 and HTLV-2. Retrovirology. 2019;16(1):21. doi: 10.1186/s12977-019-0483-0. - DOI - PMC - PubMed
    1. Schierhout G, McGregor S, Gessain A, Einsiedel L, Martinello M, Kaldor J. Association between HTLV-1 infection and adverse health outcomes: a systematic review and meta-analysis of epidemiological studies. Lancet Infect Dis. 2020;20(1):133–143. doi: 10.1016/S1473-3099(19)30402-5. - DOI - PubMed
    1. Eusebio-Ponce E, Anguita E, Paulino-Ramirez R, Candel FJ. HTLV-1 infection: An emerging risk. Pathogenesis, epidemiology, diagnosis and associated diseases. Rev Esp Quimioter. 2019;32(6):485–496. - PMC - PubMed

LinkOut - more resources