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. 2023 Jun 30;9(7):e17803.
doi: 10.1016/j.heliyon.2023.e17803. eCollection 2023 Jul.

Adropin - A new player in energy regulation predicts long-term prognosis of patients with acute myocardial infarction

Xiansong Chang  1   2 , Fulu Jin  2 , Li Wang  1 , Yufeng Jiang  3 , Peiyu Wang  2 , Junyan Liu  4 , Liangping Zhao  3   2
Affiliations

Adropin - A new player in energy regulation predicts long-term prognosis of patients with acute myocardial infarction

Xiansong Chang et al. Heliyon. .

Abstract

Background: As a novel energy homeostasis regulator, Adropin not only plays a vital part in meditating energy metabolism, but also has a certain correlation with atherosclerotic diseases. The purpose of this study was to evaluate the effect of Adropin on the long-term prognosis of patients with acute myocardial infarction (AMI).

Methods: 162 recruited patients with AMI were divided into low Adropin group (Adropin<166.3 pg/mL, n = 82) and high Adropin group (Adropin≥166.3 pg/mL, n = 80), according to the mean value of serum Adropin level. Patients were followed up and major adverse cardiac events (MACEs) were recorded. The Kaplan-Meier method and Cox regression model were used to evaluate the survival of patients and the related factors of cardiac events.

Results: Diabetes was more common in low Adropin group than that in high Adropin group (P < 0.05). Patients were followed up for an average of 50.3 ± 19.2 months. MACEs occurred in 37 patients (22.8%), including 6 cardiac deaths (3.7%), 14 recurrent myocardial infarction (8.6%) and 17 rehospitalization of heart failure (10.5%). The incidence of recurrent myocardial infarction in low Adropin group was higher than that in high Adropin group (13.4% vs 3.8%, P < 0.05). There was no significant difference in the overall incidence of MACE, cardiac death and rehospitalization of heart failure between the two groups. Kaplan-Meier method (log rank test) analysis results showed that patients with low Adropin had lower survival rate without recurrent myocardial infarction (log rank P = 0.035).

Conclusion: Low Adropin level was associated with an increased risk of long-term recurrent myocardial infarction in patients with AMI.

Keywords: Acute myocardial infarction; Adropin; Long-term prognosis.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Kaplan-Meier curve of Adropin on survival rate of patients without recurrent myocardial infarction.
See this image and copyright information in PMC

References

    1. Bansilal S., Castellano J.M., Fuster V., et al. Global burden of CVD: focus on secondary prevention of cardiovascular disease. Int. J. Cardiol. 2015;201(Suppl 1):S1–S7. - PubMed
    1. Liu S.W., Li Y.C., Zeng X.Y., et al. Burden of cardiovascular diseases in China, 1990-2016: findings from the 2016 global burden of disease study. JAMA Cardiol. 2019;4(4):342–352. - PMC - PubMed
    1. Li H.Y., Sun K., Zhao R.P., et al. Inflammatory biomarkers of coronary heart disease. Front Biosci (Schol Ed) 2018;10:185–196. - PubMed
    1. Ridker P.M., Antman E.M. Pathogenesis and pathology of coronary heart disease syndromes. J. Thromb. Thrombolysis. 1999;8(3):167–189. - PubMed
    1. Zhao P.S., Wu H.M., ZhongZX, et al. Expression profiles of long noncoding RNAs and mRNAs in peripheral blood mononuclear cells of patients with acute myocardial infarction. Medicine (Baltim.) 2018;97(41) - PMC - PubMed