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. 2023 Jun 26;6(3):pbad017.
doi: 10.1093/pcmedi/pbad017. eCollection 2023 Aug.

The latest breakthrough on genetic characteristics of inflammatory bowel disease in Chinese and other East Asian ancestries

Han Gao  1 , Zhanju Liu  1
Affiliations

The latest breakthrough on genetic characteristics of inflammatory bowel disease in Chinese and other East Asian ancestries

Han Gao et al. Precis Clin Med. .

Abstract

Inflammatory bowel diseases (IBDs) are complex chronic disorders of the gastrointestinal tract with the following two subtypes: Crohn's disease and ulcerative colitis. Disease presentation and progression within and across IBDs, especially Crohn's disease, are highly heterogeneous in the location, severity of inflammation, intestinal stenosis and obstruction, and extraintestinal manifestations. Clinical classifications fail to accurately predict the disease course and response to therapies. To date, most IBD genetic associations are derived from individuals of European ancestries, leading to a limitation of the discovery and application of IBD genetics in the rest of the world populations. In this mini-review, we summarize the latest progress of genome-wide association studies of IBD across global ancestries especially the Chinese population, the similarities and differences in genetic architecture between European and East Asian ancestries, as well as, the clinical significances relevant to IBD genetic study.

Keywords: Chinese population; Crohn's disease; East Asian; inflammatory bowel disease; susceptible gene; ulcerative colitis.

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Conflict of interest statement

The authors have no conflicts of interest to disclose. In addition, as an Editorial Board Member of Precision Clinical Medicine, the corresponding author Zhanju Liu was blinded from reviewing and making decision on this manuscript.

Figures

Figure 1.
Figure 1.
IBD-associated genetic loci in Chinese and other East Asian (EAS) populations. There are 80 genetic loci significantly associated with CD, UC, or both in the EAS population (P <  5  ×  10−8). Among these 80 genetic loci, 16 genes are new IBD-associated loci, and 26 genes have been identified in the EAS population previously. A total of 54 genes were first reported in the EAS population, while 38 of these 54 loci have been reported in the non-Finnish European (NFE) population previously. The three tables show the most important IBD-associated loci based on the odd ratios (ORs) and P values. ORs and P values are from the inverse-variance-weighted fixed-effect meta-analysis (two-tailed) including all East Asian samples. *Nearest gene to the index variant.
See this image and copyright information in PMC

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